Joe Rogan Experience #1054 — Dr. Rhonda Patrick Transcript

Transcript

0:00 My boy woke me up at like every hour. I'm hoping I don't have mommy brain. science. And I felt, you know, I didn't feel that calling to like, I've, you know, really driven and loved what I was doing in science. And I felt, you know, affects me as much like stress of various things in life you know I just look at him and you know And then I'm like, this is the way I like to live life.

2:38 reproductions right yeah I mean you're passing on a lot of the same you know but did you, what did you do to act on that, I should ask? So fish have DHA, like 1% of their DHA is in phospholipid form. 10 times better was enough ammunition for me to be like, Alzheimer's disease and basically a bunch of, you know, dementia type of problems. I was eating salmon roe.

6:53 The fish eggs are bigger. Well, I mean, the salmon eggs are like... Like, so. Probably a small amount, yeah. I don't know. bit and it made me a little nauseous like what if your kid can read minds what if like it comes out Like, I could send it to you. So, of course, Dan and I were all super pumped. He's making noises. like right away like and she stood up quicker too she's she was standing at like nine months old

10:53 Like as a little person too. There's so much work that goes into it. You know, if I if we if I want to have another child, will I be able to do it? You know, it's because I really just want to. but the fathers. But what was super interesting was that these men, they were morbidly obese or very obese. They underwent bariatric surgery and their sperm DNA

13:25 conceive might consider their health before trying to procreate. I'm not saying that you And it's just by your discipline. Which is crazy. I mean, so it's definitely a very, it's a growing field. They try to lose weight and, you know, they have to find the right combination of things that works for them. You know you're unhappy with your physical body and you refuse to do or for whatever reason don't do enough.

16:37 guilt. I was like, this hurts my feelings just watching that. my like my stepmother for example her generation also my grandmother, they didn't know about this. In fact, it's like the third most common factor in breast milk behind lactose and fat. Those short-chain fatty acids like lactate, butyrate, acetate, things that you've heard of, not only are they feeding the beneficial bacteria, well, recently it's been found that

20:31 but in animals in preclinical studies it's been shown that those that those breast stem cells And a lot of women give up after like the first two weeks. So like he, when he opened his mouth and he'd latch on, there was a little bit of problem. You know, but it really it's not easy for everyone. There's all sorts of problems that women have. I understand now. I think previously I was like, how can anyone not breastfeed?

22:54 Breast milk being breastfeeding, I'm sure, being one of them. Like, don't put that in your mouth. He was talking about how much he loves his rabbits. He goes, my cat wakes up my kid. Like if I was on a plane and babies were crying, I used to be like, God, this baby won't shut up. creates so much empathy I mean it just my whole perspective of what a person is is different.

24:59 Jamie used to be a four-year-old. way nicer to people. man, He's kind of like I wonder if just like becoming a mommy like you just all of a sudden more creative, you know It's so dumb. because she's funny, I feel that way with my four-month-old. I game with me it's like it's so odd i feel that way with my to have children. But I think for me, it was, it was very much, there was a, there was a giant learning experience

28:19 Time stress, financial stress, lack of sleep. And that's, for me, something that really helps me that is exercise. I mean, it's like a hundredfold higher. And estrogen has been shown to increase the expression of a gene called tryptophan hydroxylase 2 in the brain that produces serotonin from tryptophan. You're like, I don't think we left. So your circadian rhythm, which is, you know, extremely, extremely important for mood, for the way you feel, that is completely disrupted because you're waking up, you know, multiple times a night and that's completely gone.

31:11 which are serving other important roles, but you're not getting that tryptophan. So that's another thing. like there's there's images all over the place where they show like before and after and there's Maybe 26. whoa he's 28 some 26 28 whatever he was he was under 30, and super athlete. And they were stunned. And then you started going into detail about the various things that were happening.

34:27 but like the actual, like getting your head bashed and stuff, It's not just money. And the game is I want to try to hit you with my bones. I think that's what I meant when I was saying something that looks kind of cool. They're trying to counter, and they're both black belts at a very high level. Yeah. For sure. last like most exciting fights and it was like he i mean it was it was crazy yeah for sure and and i think i we talked about this you know last time you know a couple years ago but the apo e4

37:04 But when you have two copies, And you probably would find ones that would say, Yeah. just so, you know, it's so damn important. you have to survive. And if you don't have a starting place, a starting, if your baseline You know, I, for the longest time, have been a runner. Where you're not present because you're worried about this other thing you have to do.

40:09 mine had a run uh in in vegas uh 5k i jumped in it with zero running at all and i was like god But it's essentially hill sprints. I was super excited. Like, there's, you know, so I went to my OBGYN, talked to him. And so he was like, well, you probably shouldn't have started running so soon. So it's the, it's a, it's a spin class where, um, you do hills and sprints and it's, it's

42:52 If it were just me on that bike for an hour, Or the group. And then there's the instructor where they're like a coach where they're like they're trying to help you get better so um so i got into this high describing was your aerobic capacity changed. It's changed for the big one is kickboxing. So what you're experiencing has been studied in clinical studies.

45:17 which in this study, it was like they were 40 minutes long and there was four minute pushes. important. that I've gotten from these hill sprints. But what's really changing for sure is that my aerobic capacity is just way bigger. Like, I love it. I mean, it's definitely good. as being detached from what we experience just in terms of even just visually.

49:01 There's something going on. you're breathing in pollution and that has been shown to increase inflammatory biomarkers and all that. people yeah it was fun it was close to the beach and yeah you know it was it's fun like but just Those Harley Davidson guys. But it's hard. It's hard in California. You know, I mean, like we were saying, you know, it's not easy. So there's things you, there's just all this stuff you have to consider

51:01 See more evidence. find out from like the 1960s were terribly detrimental to children and I mean, right out of the box, a lot of doctors want to give your kid a series of shots. And and that's kind of like, you know, if you look if you look at the literature and and how the immune the immune system responds to some of these vaccines studies now in non-human primates that have looked, and these studies came out of UC Davis,

55:05 are five times more likely to have antibodies floating around in their blood it's a little more inconvenient because you have to go to the doctor like so many times to do it. But the real problem is until you look at how much work has been done determining what the consequences are and how can you find out? And we know that people who don't vaccinate their kids, they're the reason why measles

57:31 Yeah. Yeah. I mean, I completely 100 percent agree. may, you know, predispose a child. Now, how are you going to know that, like without doing a DNA Just having this conversation, Joe Rogan and Rhonda Patrick are anti-vaxxers. The thimerosal guy, the doctor that got disbarred because he falsified some data on thimerosal, the mercury, causing autism.

1:00:34 to my understanding was that he just pulled it up here journal retracts 1998 paper linking autism in the scientific methods among parents groups in the United States. but I know there's a massive amount of money to discourage any sort of talk and thinking. We were talking about this before the podcast started that we were going to discuss. But I mean, they don't do anything negative to me.

1:02:50 There's going to be something that happens in your body. to be a small percentage of a chance that your body has an adverse reaction those chemicals I mean, you know, some people have, you know, type 1 diabetes Protein's bad. No, it's good. You've got, you know, all these camps of people that all, you know, you know, various foods, you know, different at different rates, because they were, you know,

1:05:45 were measured every five minutes. And these people were then they submitted samples for their for So people, you would think, well, people are going to have a high blood glucose response to white bread, maybe somewhat to the banana, but there's fiber in there and that sort of effects. They can have a higher blood glucose, they can have higher LDL cholesterol, they can

1:08:18 compared to my husband, Dan, who doesn't have an APOE4 allele and we eat the exact same diet. oh, this person eats that, and they have a higher risk of that or a lower risk of that, right? If you just look at the birth records and the death records, you'll be like, oh know, you know, move and move to Florida. So you just look at the data, if you just look at the birth records, and the death records, you'll be like, oh, people are born Hispanic, and they

1:10:30 all cause mortality, boom, I'm going to be a vegan. Well, guess what, lots of other things Every time you make a new cell in your body, guess what? things happen. And it completely increased their inflammatory biomarkers by like 100%. Right. And in combination, you have people that are drinking orange juice or even worse, eating cookies and cake and drinking soda and bread.

1:14:27 You have to look at observational studies are also important. Triglycerides, inflammatory biomarkers like high-sensitivity C-reactive protein. to know what your LDL is because you don't want them to have some opinion about it, Wellness FX have been starting to uncover these mechanisms but it's a lot of clinical trials and a lot of things before any sort of regulations are

1:17:36 that because it's like anyone could do that. I feel like really the response that someone should because I found out I had this allele and I knew there were sorts of risk. them. Their inflammatory biomarkers went up, their small dense LDL particle went up, all this stuff, Because, you know know first of all variations in that gene that don't do it very well. And so the high-fat diet, what ends up

1:20:42 the biomarkers first. And if you're Low fat, high carbohydrate diet. the way your mitochondria age. Like it really seems to help your mitochondria age better. So that and this is like all these questions for him that I asked him about. even if it's ketogenic, they'll just, they'll keep eating. Like they'll just keep eating it. Like, and, and they can become, it can become an obesogenic diet where they're,

1:23:41 carnitine palmitole transferase for those nerd nerdy biologist geeks out there. That, you know, so anyways, I totally digress there. But it's, And my blood glucose levels have always been pretty good, like fasting blood glucose and all that, with the exception of my lack of sleep something called electron reducing equivalence, and they can be in the form of NADH ratio or FAD2H.

1:26:06 You're just from normal metabolism. from the fasting part of the time-rest time restricted eating, right. But I've become cooking with coconut oil, which is high in saturated fat. And I'm like, what do I need to do that for? So I don't know what my baseline was, but I did measure the large. I'm not sure we entirely understand that yet. You measure their small dense LDL before giving them the refined sugar, same diet.

1:29:00 sugar have like telomeres, which are a biomarker for aging that look 10 years older, levels, feel the difference cognitively. The cognitive thing was a big thing. Different requirement. Weightlifters. Right. through the roof and so you start the glucose from your your bloodstream gets like sucked into the great way to go i think the one if you were to think about the one easiest thing that you could

1:32:38 Like that's probably the biggest thing, the easiest thing. of bacteria are. And those bacteria actually eat the fermentable fiber that we don't digest, The second thing that happens is what you mentioned, be is that it causes the same response that eating gluten causes, where it basically, it's also the one of the reasons like I was saying, you know, with, and I've never actually

1:35:50 His wife is much more resilient, nad so this is something um what does nad stand for again nicotinamide adenine dinucleotide and And it's kind of like triaging. there's a way to replenish it through supplemental form called nicotinamide riboside. So NAD is undergoing one showing that you actually can take the supplemental form of NAD, I think that's something that is now popular everywhere.

1:39:53 Have you done anything IV? I mean. know if it's placebo or really you know because there's no data yeah so it'd be it'd be kind of nice if like people would start to aggregate data on that but well you know it's it's really that red meat is negative for you. But you're not taking into consideration all the things of a variety of different foods, the results. Right. You're making a really good point. And that is the combination of how these

1:43:18 protein intake and all-cause mortality and cancer mortality. And it found, like a lot of other studies, foods, you know, that's really important when we're, when we're looking at these observational does refined sugar have less of an impact? Yes. You illustrated it perfectly. So if you were to take that same population of people and say, okay, eat your saturated fat, but take out the refined sugar, we may see the same thing where the heart disease risk goes down just like it does with saturated fat.

1:46:56 I'm confused about something you just said. of a negative synergistic effect that's what that's what the data in aggregation looking at They think that this is just too simplistic. we know that from mechanistic studies. And, you know, that's kind of a big part of the eating protein, essential amino acids specifically, what does do this, and they're found in animal protein.

1:49:29 a deal because you don't have all these damaged cells from all this refined sugar you're eating It's like, this is not what the problem is. People can do it to various levels. isn't so much that as the IGF-1, Then you're allowing the IGF-1 to allow those damaged cells because you're eating all this other crap, which is causing damage, then you're allowing the IGF-1, you know, to allow those damaged cells to grow.

1:51:37 they also inactivate those pro-carcinogens. because clinical trials have shown that. Like what is, but is there a difference? omega-3 fatty acids are in fish are a lot of irons and in red meat. So there's differences in the micronutrient concentrations. I mean, omega-3 fatty acids are in fish, a lot of irons in red meat. And then the ratio of the proteins are different.

1:54:17 I want these micronutrients. My mentor, Bruce Ames, who I talk about a lot, he was the inventor of the Ames test, It was to prevent them from – it was a flame retardant. And then he went into people and found, you know, there was like a really small pilot experiment, And that became his thing from the 80s on. And so- Yeah. Yeah, where it's like it was totally counterintuitive where DNA damage usually causes telomeres to get shorter.

1:59:10 He actually discovered folate by isolating it from spinach. Kale is a really, really great source of it. So there's things like that. you supplement with like 20 mg a day, improves cognition. It also improves markers of mitochondrial but then it gets oxidized again and it can do it again four times pqq does it 20 000 times So and like, again, you can, you get it from plants,

2:02:54 do you have a supplement company that you rely on the most i do so the thing with supplements And one of the companies that was just really, really, really good and reliable was Thorne. Yeah, it's a difficult issue. Wow. know, things aren't being cleaned right and there's contamination and all that. A lot of people have a hard time digesting all of this data and trying to figure out

2:06:20 blood biomarkers, I mean, there's a few that are really, really key, I think, It seems like there's room for a company to do this, like a one-stop shop company that sort of analyzes your health and prescribes to you, you know, explains to you what's lacking in your diet and what you could benefit from and what you can't. And is it a nationwide company?

2:08:08 That's always the catch, right? I can't do this. I mean, the problem is we're still figuring out all those nuances. Yeah. Because I had heard that Peter Thiel had done it. Peter Thiel denies ever getting injected with young blood. Okay. Oh, is there? And they're definitely- So is this really credible? Jazzy Karmazin agrees his startup Ambrosia is charging about $8,000 a pop, expensive,

2:11:29 like, like, well-known, Bullshit. I used to have a joke about Dick Cheney. Sort of. You'd have to monitor them like you would someone like the surrogate moms. It's not just fresh blood. What does it say? And they're like, oh, that's not replicatable. But I was gonna just mention to you i was telling you your microbiome makes these short chain fatty acids and it totally regulates your immune system it you know you

2:14:54 That's not an average age that most people make it to. Of course, like, I think the problem was like making sure it doesn't taste like shit when it's going down. So the Stevia, it's a non-nutritive sweetener. They change the bacteria. New York Times story. 12 cans of Diet Coke. Trump drinks 12 Diet Cokes per day what can that do to where it seems to improve insulin sensitivity, which is kind of weird.

2:17:39 Cacao. So I didn't consume any during pregnancy because I was worried about that. improve they don't they you know they don't want the refined sugar yeah they don't want to have the It's cold. all sorts of interesting studies that have shown effectiveness of certain probiotics So the so really a healthy diet is the way it's not you can't just counteract with supplementation, healthy, healthy diets, the way meaning, you know, the the

2:21:09 but it's like a little cheaper and I don't have any affiliation with either of those companies, So there's, you know, again, the immune system, modulation of the immune system will affect the brain. right foods to to get our microbiome healthy and avoid things like, what's it called? Aspartame. Yeah. types of reactions like refined sugar. So things like that definitely have been shown in animal studies.

2:25:13 Right. But still, I think it's good if you've got the prospective studies in humans a connection there. And there's been animal studies where you inject them with human tumors. And literally, it can, you know, if you give these animals a big dose of probiotics, and natural killer T cells and all that. And probably one of the least understood in terms of the general public.

2:28:45 corresponds with the rise of refined carbohydrates and refined sugars in our diet, a couple of studies have published, I think even recently, it just kind of a big one came out that was confirming. Because most people think it's maternal. Yeah. So that, that seems to, and that's something that's a couple of studies have published. I think even recently it just kind of a big one came out that was confirming.

2:29:45 with, you know, the quality of the DNA in a woman's egg or man's sperm and the type of diet they're so so drastically changing the fat composition that they just kind of always say So it's because, and what was found is that the obesity was changing genes that regulate pancreatic beta cell insulin production in their sperm DNA. It's interesting. The studies, rather, with the scientists were paid off by the sugar industry.

2:33:27 And what my work found was that, to my surprise, so blueberries lowered DNA damage, which is what I thought, because they have a variety of compounds in them that are known to be antioxidants. was being activated. Well, it wasn't really robustly being activated in the blueberries, So it's not always the case. And all of a sudden, it's the complete opposite.

2:35:35 Oh, it's fascinating. Like we talked about one last year, but there was another one that came out, another study. one. I usually don't say this. Like, I usually don't say like, you know, based on who funds the you know, processing these things. I mean, what percentage of our food do you think has sugar in it? That I kind of get. It's in the bread that you consume it's in the pasta it's in the spaghetti sauce it's in i mean it's in everything it's if you go down the the aisle at a supermarket and just grab a random

2:39:25 I ate as like a girl and I had in it, right? I don't know if that one She's so gross. Great. What's in there? Spices. Do you limit the... More. Does it say ingredients Nine grams. it's very weird. Yeah, but the nine-year-old is just psychotic. Yeah, she's straight up psycho. She has a six pack? she eats everything it's not like she's like uh you know like anorexic or anything she just

2:43:08 little girls love other things where other little girls are also being active. And I, My mom says I started when I was two and a half. Do you still surf? I am, yeah, I'm getting a lot more worried about the sharks. And all it takes is, I mean, they're eating machines. Is that a great white? Where is this? like in hawaii i was terrified we did this one cool thing where uh we were on the big island

2:45:41 like this they don't have anything to do with you. Why are you monitoring your heart rate? that's in your face every day. is because I'm a really go, go, go, go kind of go-getter, Oh, my goodness. But where it's just so powerful. out on a boat all the way out until near mexico yeah they get towed in and then they just jump I'm friends with Shane Dorian.

2:48:25 he's, here it goes. really? And he's right. is his life he loves it i mean i think he's been doing this for a long time it's just a natural I mean, the Big Island, like, you always hear about people getting bit by sharks, especially tiger sharks. It's crazy. I'm planning on it. Four months old. time. I think the organized So I have like weights and

2:51:13 So, you know various various different exercises were done like hand grip strength and all that but it and then as you go down your heels come up off the ground like this and then your hand touches So your heels come all the way down when you come up? You know, I'm sure you know about all that, where Nike sort of changed the gait. Which is not good.

2:53:50 I used to be a jump roper. But yeah, so I started jumping rope it was called the come here early we'll set you up with the isolation tank we'll do a sauna we should do a podcast we at a running shoe you think of an average running shoe the average running shoe has a lifted heel I run in those. And so I didn't really like it. So. Because beach running is probably a lot easier too.

2:56:33 Like just don't run as long distance or something? Because your feet are weak. And you have to be careful with it. I think I was running on treadmills as well, too. He fucked up his feet. I think my mother-in-law had it. I mean, just my feet just feel stronger. I noticed a big difference in yoga. Maybe it's like, did a lot of exercises with that 40 pound vest, your bones are going to get more dense, right?

2:59:33 Yeah, they're wider. So I actually gained. I know I'm going to gain 80. They're going to be stronger. I have this thing. wearing a backpack and you're going into camp, you could carry as much as 70, 80 pounds on your ways to prepare yourself for that it's really one of the only ways because you're dealing with many Like there's no way I could do that much.

3:02:57 Come on, man. system to clean out the water to make sure that they don't get, you know. Parasites. Yeah. Yeah. But the point being that weighted backpacks are an excellent cardiovascular exercise. gonna do it again or are you one and done i think i might be one and done um i don't know for sure It's okay to have one kid. There's always going to be.

3:05:52 And being able to do other things too, like science. the episodes. And if you click on one, there's like a summary and sometimes we're getting You haven't looked at notes once. And next time we'll do the tank, You've got to see the jump rope.