Joe Rogan Experience #1683 — Andrew Huberman Transcript

Transcript

0:00 the Joe Rogan experience can add a little THC to it yeah I can imagine yeah THC probably takes the edge Street side chemistry. I was talking to Matt Walker about this, my friend Matt, amazing sleep scientist. Melatonin, if it's listed like three milligrams or six milligrams, it can vary anywhere from being 15% of what's actually listed on the bottle to 85% more.

2:13 One is the reason kids don't go into puberty until a certain age is because they have chronically high melatonin. Humans can breed all year long, of course. with falling testosterone, dysregulated estrogen melatonin is it will help you fall asleep but it won't help you stay asleep and so some people have Well, and then theanine is also that is the third thing in the cocktail.

4:52 Three and eight. because when you take magnesium, it goes into your gut. It doesn't necessarily get into your the isolation tank and the sensory deprivation tank is all filled with magnesium. It's all filled Yeah. So citrate has its value. Malate, again, it's good for muscle soreness, but three and eight, Did you just put this together? But those are the three things.

7:36 50? So apigenin turns on a chloride channel. Uh-oh, I hate that term. It can block estrogen receptors a little bit, but it's a very weak affinity. Years ago, I worked on hormones and development. We could we could go there. Hormone effects on the brain. That was my master's thesis. But the but theanine, T-H-E-A-I-N-E is also has a little bit of an anxiolytic and anti-anxiety effect. And there is something to think about with theanine. People now put theanine in energy drinks so that people will drink more energy drinks and not get the jitters.

9:31 But I'm into dreaming. So that's another reason. I'm not prescribing anything. Well, he scared people a bit. Yeah. Yeah. So we talked about that. I mean, like, I think but I want to be really clear, plans for the world Oh great, which I just think is gonna help so many people sure and brief would make it nice because it's easy to digest I can't help myself.

13:12 There's a new version of alpha brain that's been really beneficial to me. You know, the best way to work, the best nootropic is something that's going to put you in alert but calm. bit of a reduction of cortisol, which is good. Most people are riding high on cortisol which is critical, right? I spoke to my chairman of ophthalmology at Stanford, asked him, what's the story on lutein are good. It supports healthier vision. Yeah, I take lutein every day now. I spoke to my chairman of ophthalmology at Stanford, asked him, what's the story on lutein? He said, for

15:13 I have another theory, which is you're living in Texas now. And just being outside in natural light seems to help offset vision loss. And the reason is that when you look We don't have to get into the details. the progression of HLA macular degeneration. Now, people shouldn't be blasting themselves with looking at things up close and the visual system and the brain will adapt to that. So kids that

17:53 Yeah. how old is he's my age that fuck i see his his running videos it's impressive freak well he's I don't understand how his joints are holding up. Yeah, I've been- I have always had an anterior tib machine in my gym. And then I started using the anterior tib machine and it went away. with my body you know at 54 almost 54 next The ability to jump, they're very well correlated with health and well-being and the ability to, I think, as Sinclair says, you know, hip fractures are a big cause of early death.

20:51 Anyway, it seems to- Oh, yeah. and it makes me realize, like, oh, it's so painful these ladies beat the shit out of me the roll thing it's just deep tissue it's just He shows all these different exercises. Yeah, public education. I I love what he's doing Wow. guy. Um, and he always says, you know, if you injure a joint, you want to work things above

24:29 Couldn't do a lot of things. Ready State? If you beat it up, because they're using different surfaces, different people using different plastics and ceramics and different things to resurface the knee. He was running while his knees were just mangled. them suctioning all the stuff out of the knee and he was doing some of this no anesthesia just so and we're getting the people.

26:57 When he did that, that's one of those- but I'm still learning from friends, and I saw that ankle break. He got it scanned. What's wild is a week before this. On the same ramp? Wow, that's incredible. I mean, he's always had that. and he got it scanned. Not the one that Dustin thought. it kind of buckles right there. Now, as it puts it down, his shin is shot now.

30:48 and as he throws the front kick, Watch. and to have all these breaks in a row. The craziest thing is Chris Weidman, Hall checked it he broke his leg crazy it's crazy the odds the odds of these The ones in Nevada are getting really good, and that's the gold standard. Ground game's complicated. And sometimes there's techniques that these guys are doing that I'm like,

34:12 Like jujitsu is, you know, there's two arms and two legs and a neck, right? guy i mean i like i like i like physical effort yeah um it's it's a it's a serious time commitment be fun man there's a lot of places on me there's a lot of places in uh where you're at out near uh days a week and he never takes days off, including holidays. He takes no days off. He has no family.

36:48 He might be as good as John as a coach, Let's start in that position and let's analyze it. around in the lab and it's a process. It's an amazing art. It really is. It's, it's just too hydration, physical exercise, all the things that you talk about and that I certainly believe in wholeheartedly that's really interesting. prescription drugs, and then off-label stuff, right?

39:38 Oh, yeah. Because what happens is the testosterone molecule, and albumin, they carry the testosterone molecule And so we're not talking about full TRT or blasting or now that I'm always amused on YouTube, they now call it sports TRT. That's when you get above 200 milligrams per week. One cc? I mean, I actually think that a lot of people who think they need TRT, when I hear about

41:50 And it'd be an interesting conversation to talk about the role of testosterone in neural repair. So taking this massive dose and then waiting two weeks actually problems with prolactin, which is a molecule that's involved in milk letdown and Wow. I'm mostly co-parented. We all know women do far more, but it's true. which is the hormone that comes out of the hypothalamus that stimulates the testes if you

44:44 And he got it up to the 700 off. Although, and I'm not going to out the organization, but there is one major professional Although those guys have the head injuries. The major mental effect of testosterone So if you think about I'll probably pick an example where you'll know the exception because I know you know a lot about natural animals and animals that are hunted.

46:59 John Pletka And the fighting is a choice, right? in order to fight for the right to mate. when people have a surge of testosterone they feel relief and anxiety provided it's in the It's a lot worse than that. But they were saying that, you know, these squirrels, they're only in estrus for a short to rescue the other member of his species. So in species where there's pair bonding,

50:50 females from getting access to the, to the, the sires, the males that were are desirable there. The girl wouldn't open up the door. It's really wild. these days there's a lot of discussion around, oh, you know, if your testosterone is too high, No anastrozole, none of those things, So prolactin is what's causing that growth of breast tissue. Cause I went down a rabbit hole

53:58 you will see that people who take opioids like with the opioid crisis or heroin users, the reason why they get breast development We know this. I mean, Yeah, so women have some testosterone. They mostly make it from their adrenal glands, they will release more dopamine related molecule, which is called DHT, dihydrotestosterone. That's what causes you to

56:59 really hard look and the females in particular female bodybuilders like that gives that really the meat was cooked so no one asked me but a few people reached out and i have some relationship Yes, which is a beta-3 agonist It's not working on hormones. one of the things that happens during these, And I mean, gosh, I always, I always say this, you know,

59:37 the, there's a genetic thing there, but the, They're getting dizzy. Yeah. Yeah. So don't do that anymore, by the way. They're getting educated. If he got popped for clenbuterol and he didn't take it, that's tragic. weight classes, which is insanity. It's insanity. But there's also always been talk of him being elevated. It increases testosterone and performance and recovery.

1:02:24 People buy it on the internet. It's not? are similar to ours, but different. And they get their hormones often from plants. You might And in talking to some of my colleagues who are plant biologists, they said, yeah, I'm not surprised at all. Edible or smoking? the growth of the male breast tissue. And there are going to be other people that do. You have to try certain things.

1:05:57 easily. And I repack all the glycogen that I burned throughout the day training and doing a but you know rich roll i know rich well and you know he thrives on a vegan diet yeah yeah and Be a vegan for a month. week if i am uh if i have like uh something with like if i have sushi right like a lot of sushi But I'm always so tired. And I'm almost, like every day,

1:08:02 then I'm doing stand-up at night a lot of these nights. I'm tired. There's quite a few of these companies now that are, So when you wake up in the morning, on when you're waking up. As that temperature drops, it's going Oh, that's magic. growth hormone release. If you do it regularly, you kind of adapt to it and you might say, well, And then that exercise in the day also sets you up

1:10:53 I asked my colleague, Craig Heller at Stanford, It's the hairless skin, do this subconsciously. Whereas if the room is too hot, what are you going to do? You're going In the palms of our hands, in the bottoms of our feet, and in our upper face, it goes if you're overheating, people will put like a cold ice bucket have done some work, and we're starting to do some work,

1:13:09 And this has profound effects on athletic performance by effectively taking like something like this. There's a device that Craig has, they have, And then it kind of drops 10, 10, He's increasing volume and repetitions. We're watching a video for the folks but you're cooling off the heat of the body. That's failure, is the heating of the actual muscle tissue.

1:16:02 rounds properly, not by putting ice on the back of the neck, which just feels good, but by actually cooling the core of the body. I think one of the things that happens with boxers in particular, with deaths, is most of them, like the vast majority in the lighter weight classes, depending upon the local commission. And then they would fight the next day the fights would start somewhere roughly

1:18:12 So now I say, you know, Jamie Vernon, official weight, 190 pounds, Neurons need salt. hydration test that they use on athletes i know they also out of Singapore and they have some sort of a hydration test that they break records. No one wants to see everyone run progressively slower in the Olympics every year. Like, especially when you get into the heavier weight classes, like there's a gap between middleweight and light heavyweight.

1:21:21 And again, there's bad weight cuts where it doesn't work out well, the longevity of the athletes, the longevity of the athletes, He's fucking big. Maybe I'm wrong. in and then rehydrates himself up again. It's just bad for you. It's just bad for you and it's a And that's totally understandable, but it should be illegal. eight pounds over that is super middleweight right i mean it's uh and then uh seven pounds over that

1:24:53 I don't know. I think Tyson Fury had the opportunity if he fought Anthony Joshua to or you know, either one He's an animal. He's hilarious. What a dumb move England did. comfortable with it. Years ago, I was down in Australia for a meeting called vision down under, sessions, the jellyfish will fuck you up. Those things scare me because I've have just gone during one of the breaks or probably during one of the sessions. The jellyfish will fuck you up.

1:26:53 It's bad. I mean, it was poisonous, but it wasn't something that can kill you. what, you know, the chemicals that neurons use to communicate with one another. And they were all they work at what we call pico molar concentration, you know, from cans. It blocks the- It seems like more and more nowadays. And why is it shiny? It just sits there flaccid.

1:29:41 You would just, everyone would just asphyxiate. Their lungs wouldn't work. You couldn't move that releases acetylcholine Is that extremely toxic to the point of death? I used to see them all the time in California. but snakes freak me out. got hurt. It's hard to remember because I was 11 years old either i was there or i heard about it you out and snatched the toddler and dragged it into the water and ate it.

1:32:24 226 alligators were removed from Disney World world since toddler's death five years ago imagine yeah let's just hope it's He's a famous kind of celebrity photographer in Hollywood, does all the Marvel stuff. He's got one now. you understand their behavior a little bit, you can maneuver there. But these saltwater crocodiles, and he's got this croc,

1:34:02 you have three kids. There was the guys missing an arm a lady would miss a leg people with like bites taken out of their thighs Just put away as many as you can. around for yeah in that form i think they're older they are dinosaurs because they're older than the But they have huge olfactory bulbs compared to a sighthound They just go in. this 22 inch neck. And I'll actually, I'll come clean now. Cause maybe the veterinary world will

1:37:27 Why not just take, not have them clip? I had a great doctor in Los Angeles that told me, And he's, you know, and he can't repair his joints. The moment he started getting regular You can't castrate a male animal unless you have an exceptionally good reason to do it. And she goes, what are those there for? Well, she was just making it seem like it's a mandatory thing that you have to do to a dog.

1:40:26 I mean, you ask any post sort of perimenopausal woman how they're feeling. Somebody who knows the veterinary world better than I will probably. Yeah, I'm not a big. courtyard or something fucked up and landed in that courtyard, she would just slowly creep up on it. Do you know about this? It's what we call no-go. We have go functions and we have no-go. Don't do it, don't do it, all the impulses. So when you want to eat something, you're like, I shouldn't, that's your forebrain. It's, it's what we call no-go. It's a, it's a, we have go functions and

1:42:53 because they're very calculating. And that teeth chatter is a little bit of behavior And then I wrote hashtag vegan. I want to get very important so I get to the And this is a total true story. Yes. This cat's like, where the fuck is the real food? I mean, you have to This is why I'm not a hunter. It's a great follow on Instagram too and on Twitter as well.

1:46:47 Hunters and ranchers really understand the relationship between animal and human. game animals on this planet because of market hunting, because there was unrestricted, And they brought in this incredibly prolific animal with no predators. You can't believe how many eyeballs you see looking back at you. And there's like us and a couple other hunters who are like top of the food chain, like Adam Green Tree and Remy Warren.

1:49:57 fast so i have a video of this axis deer that i shot out at uh it was like 80 yards. So I'm like lined up on this thing. The bow goes One was successful. Maybe you could explain because I'm curious. So you're, you're staying at the beach in paradise. Very primal, but it's a family. I'll kill it's also it's one of the best places to hunt intermediate animals that act as what we call vectors and they, they will cross the line for us.

1:52:56 It doesn't jump yet. One of the reasons why they're in denial about it is because like many things there's a financial incentive So they feed these deer. Yeah, it's madness. Dumb humans that want massive antlers from a deer. That's an animal that survived like nine years. The people that run this, it's all like free range, wild animals, but they won't allow anyone to hunt an animal that's less than nine years old.

1:56:08 Now, here they are in, you know, when you're around nine years old, an elk, if they're lucky, lives to be like 11 or 12. out before it spreads its genetics. In fact, it spread its genetics for multiple seasons. and this this idea of taking that and bastardizing it and feeding these animals this insane diet out One night I was at the movies in San Francisco.

1:58:21 They were throwing pine cones. Not in a creepy way. Right. It's not just roam. They have a deep desire to kill. That's part of what they do. There's a reason why they exist. They exist because there's a balance in nature. You have prey population like antelope and these axis deer, which are the ones that evolved with tigers. and the goat would wander.

2:00:24 and this door opens and these lions just come pouring out. This is the video. So these goats are hanging out. Hey, how's everybody doing? Sure. like this group of neurons are all densely packed together, but with modern methods now you can some that are responsible for mating and some for fighting. Wow. Some primates don't. She's an amazing dog, but you know, she's pretty dominant pit bull.

2:03:45 of course, in humans, this is a very thin line. Yeah. And who knows, right? But let's face it, there has to be a circuit in the hypothalamus and when you kill an animal and then eat it that day over a fire, it is like a door opens up to the past. kids hate it man i tried to get them to eat it what if they didn't know what it was they would The gall of him.

2:06:27 You don't want to go too high. It's all desiccated liver and heart. Yes, there are really great ethical ranchers where they have these cows that live an amazing life Yeah. That's an excellent example of an ethical farm. That's the problem. and ranchers, they understand this relationship. That's what I was going to say, because You're here for a couple days?

2:09:03 It's like a super athlete. I've been really fortunate, but I also have a really good guide that takes me. Yes. I think, granted, I don't understand the whole thing He runs 240 miles. Bow hunting success, general bow hunting success, understand that for a lot of these people, there's a badge of courage's tied to finances and I understand that for a You'll go 20 miles in and you'll see a fucking wall tent filled with five guys.

2:12:14 highfalutin fuckheads like me who can afford to go to these private places, whether it's just as of deer season. Wow. I'm sorry. Have you gotten into the spearfishing thing? she's beautiful but look at that she killed a fucking marlin beauty and marlin confirmed And then you'll be like, hey, man. yeah the problem with these animals the crazy antlers is not just that it's gross and that

2:15:59 My friend Doug, who owns a large farm in Wisconsin, a beautiful place in the driftless area. It was passed by the glaciers. So it's the driftless area of Wisconsin. See if you can find pictures of it. You know, usually get, The Nobel Prize it's always an absolute and basically the neurons degenerate. Yeah, that's what it looks like. to fuck this up, but I think it actually gets into the DNA of the plants, and somehow or

2:18:45 and it's getting onto these other plants. Elk is a much larger animal. Elk is my all-time favorite. A little pack of coyotes. Brutal. see them cruise through every once in a while they're fucking they're gross they are yeah they Because apparently, the mama was walking with her cubs, and this guy was on this trail, and she crossed. Isn't this wild?

2:21:47 I love them. I think it's also they're like regular cats where something goes by them fast. and we have this like really these rigid ideas about what should and shouldn't exist and how we as big as this room and he just wandered maybe twice as big as his row no one I'm not doing this. it breaks my heart it's awful it's awful all of it's awful the only thing that i had a joke about

2:24:12 another day with no lions A giraffe has a tiny brain, Oh, you don't know? They whip their neck like a whip. another thing like the darker like patterns like when the when the patterns with that stupid neck, They definitely do that sometimes. Yeah, he missed. there with a rifle with a giraffe down oh my god yeah we think of them as very placid yes and they

2:26:39 Especially if you see their mating habits, they're ruthless little fuckers. You ever see pandas go after each other? shoot bears. Like don't, don't kill bears. Like, listen to me. First of all, if you don't shoot times the density of umami receptors in their mouth, but they have, except for the panda bear, Well, this is just regular old panda sex mouth breather once a year with females only able to

2:29:07 more than a molecule of reward, is a molecule of motivation and drive. It makes you want to do more The tyrosinase molecule is actually what causes pigmentation. So sunlight causes the pellage, temperature are kind of pushing on a bunch of physiological mechanisms to make some animals This is, I mean, if you go to Scandinavia, People put their head down, it's cold. Days are extremely short. The spring hits and literally people start going, or at least they did when I was in college, you know,

2:31:55 I was thinking about this because I went to Prince of Wales Island, which is, I think, the rainiest spot in North America. Well, there's another hormone that's super cool not by tanning because it burned your skin a little bit, browning you. You're actually, What's the one group on this planet of people that want to be tan and reduce their appetite?

2:33:36 The peptide world is blowing up It just because it mimics this pathway makes you tan. They want to have sex a lot. Wow. That's fine, but I will. of this stuff so you don't even have one He went too far. Well, they're taking. So what's incredible is. Oh, is that real? Oh, I didn't know that. That was the big thing. was the carnivore diet. The carnivore diet. I started noticing like

2:38:20 But while I'm asking about this, It's an autoimmune issue. There's like testosterone doesn't do one thing. It does many, many things. So it this guy, Ryan Crowley, who tore his pec recently, this very dramatic Instagram video where you see him doing an incline press with like 515 and it rips off the bone. And he was saying, if you even inject a saline

2:40:38 not fix yeah I started using bpc-157 it was gone in two weeks yeah a lot of It's like kombucha. Or I shouldn't say it's perfect. get sores that turn into massive infections. It's so crazy. And I have great reverence and respect for the field of medicine. Not that I'm aware of. GP-157 is the one that I hear more athletes and various other communities who need to repair injuries taking.

2:44:07 maybe, you know, if it has to be distributed systemically, out of Panama. And, uh, you know, we were doing the bio-accelerator guys. Danny and those guys. This is crazy. And this was Dr. Roddy McGee did some stuff in Vegas and then we did an MRI eight months later, I believe it was. And he was like, lift here, press against this, press. This guy, well, Dr. Davidson out of the UFC sent me to this guy, Dr. Roddy McGee,

2:46:35 this is absolutely insane. I've never seen this before. I've never seen a rotator cuff tear, It's, I sleep on it. Gives birth she can vision they this country 10 years or more so it's a slippery slope and i think this is why i think people need their more growth hormone as opposed to taking growth hormone directly. They absolutely work. Because they can take certain peptides.

2:50:15 But people will take hormones, stimulating hormones. a few years ago where people were given sermorlin and told to go on very low calorie diets. They're big because it keeps your appetite down, And you know, the skeleton has to contend with that and oh so everything grows cartilage problems like with your knees would and other things like that. They absolutely work.

2:53:44 It's crazy. in the National Institutes of whatever, and etc, well intentioned, very educated people were not and communities, you can put it out there. they're just struggling to figure out, like, get oriented. What is happening in the world with By benefiting your health. Not everybody, of course, kind of a user manual for all this stuff, this technology that's been built into us. I mean, we always think about

2:56:55 clear that this podcast has promoted more health information than any other media venue, the resources, the papers, enter the discussion. we hit three hours, believe it or not, just flew by. It's four o'clock. Tell people when this Every Monday we have an episode. And we do the deep dive on some topics. So we did an episode about that. Yeah. I was about to bring that up. Your Instagram posts are fantastic. They're really good.