Joe Rogan Experience #2170 — Max Lugavere Transcript

Transcript

0:00 Joe Rogan podcast, check it out. What's cracking? and we talked about it the last time I was here and And it's a rare condition. But... the prevailing hypothesis as to what causes Alzheimer's disease, a paper was published in Nature, brains, and that plaque doesn't seem to correlate with cognitive impairment or anything like these conditions in terms of prevention.

4:38 So when you have Alzheimer's disease, somebody who's died of Alzheimer's disease, what they features of the disease that we aspire to improve for sufferers of Alzheimer's disease, a graphical depiction of proteins. Schrag, actually identified that a lot of these images had artifacts that made it very it's hugely humiliating. But no, I don't think that there's...

7:42 Yeah, and that you know you have this scientific paper you publish, And you're giving them this false hope just to boost up that have referenced that paper in 2006, that nature paper that was finally retracted Because right now when you catch it, already very late in the game. I think it can be slowed with exercise that anybody with a brain needs to be aware of

10:18 What is it? And similarly with Parkinson's disease, genes express themselves, which is known as epigenetics. But then you have your modifiable Type two diabetes, if you have type two diabetes, So it's looking a lot like Alzheimer's disease the more difficulty their brains seem She's actually in my documentary. with oxygen, nutrients, energy. Yeah, I mean, you know, I grew up in New York City and when my mom first started to show

13:42 But ultimately, she revealed to me and the rest of my family that she had So it had been described as brain fog, but she revealed that she had sought Or I think it was like, what year is it or something like that. It could be confusing. at that point titrate up the dose of a medication Yeah, over the age of 40. And it turned out, obviously, to be the case that my mom,

17:11 So she was prescribed drugs for both Alzheimer's disease and Parkinson's disease at that time. about these conditions. approaching these conditions in the wrong way, trying to acting in a reactionary way to something that had taken And so to me it became really clear that this is a topic that I needed to help amplify using that's not natural. Degeneration of our neurons of, you know, of, for example, the portion

20:33 So it was really sad and surreal, in fact, that my mom was increasingly requiring around-the-clock but it's, yeah, it's motivated me to do what I can to help. And physicians are very quick to, you know, to write a prescription, to like add a new in a system that's growing increasingly frail. air pollution is actually one of these newly identified modifiable risk factors for Alzheimer's

23:04 Parkinson's disease is now the fastest growing brain disease. disease, dramatically increased risk, anywhere between two and a half to six fold increased two and a half to three times a risk for the development of Parkinson's disease. specific crops? Is specific foods to avoid? Or how do you know if those some of them are the And it's used in cereal grains, things like that.

26:40 and of course smoking is terrible for you, but. use nicotine if you have disc issues, which are already, your discs and your back are But interestingly, there does seem It's been shown to create chronic Parkinsonism with just acute use. when they've studied patients I'm not sure. I'm not sure of the factor, the brain relies on its vascular network.

31:05 a little bit of a deep dive recently into it because because I do notice a see, like, a cognitive bit. But then I think the more interesting compound So it's a really interesting compound, cotinine in the body. That's in cough syrup 70-80% of nicotine is converted to cotinine. cotinine fear extinction or cotinine cognition. many of which I'm sure are negative, but it does seem to

35:02 and then it really expresses itself in dramatic ways years later. and that debate organic versus conventional, the publication ProPublica written by I believe her name was Sharon Lerner another journalist who I and shrouding of the truth. Yeah, I read the study about the band-aid thing and I was like, Jesus Christ, is anything or PFAS. It's. back the paperwork? I mean

38:58 exposing how the food industry pays dietitians I mean, these companies, they pay these people that are body positive influencers as well, understand what's going on. It's so disheartening that we live in this world that's so compromised by money that advice from people that are clearly sick. I mean, I wouldn't send a loved one to. And today, 60% of the calories that your average person consumes comes from ultra-processed

42:25 about, these industrial chemicals, forever chemicals. are reducing the anogenital distance in boys, And so it's crazy. Yeah, and it's so difficult for the average American to access And vitamins, I mean, we need vitamins. is somebody who is willing to present Yeah. to have the magic routine or protocol, you know, I had a health scare in 2022 that, you know,

45:53 Oh man, I have mild, or it's probably progressed, the back. Whoa. But really I use it for lower back for decompression show a video Jamie if if you would, so we could see how it worked. and you can feel it pull your back. You know, I mean this was like a couple years ago This is better. so your legs tense up and your legs resist anything better change my life that's Yeah, and I also use those kinds of things with weight

49:52 No, everyone that I know has had problems. And I have some friends that run a clinic down in Tijuana, the Cellular Performance Institute. They don't want any stress on the back, anything that's going to impede the healing process. and you could do it again. Now you have less disc tissue. tilting over a sink, putting on my underwear, but you clean and press a kettlebell, and then you turn to the side core, but it's you clean and press a kettlebell and then you turn to the side

52:33 Phenomenal. You know because it it it strengthens all of the connecting areas instead of strengthening when it comes to weight lifting and developing problems, How are the things behind your calves? How are you know, how are your tib muscles? How was how's your lower back? It's just limited in the sense that like my I don't know what I don't know Whoa. Whoa, and so what a slant board is is a board that you do squats on where the back of it is raised

55:41 and I never do like regular squats. The heaviest thing I squat with is a 100 pound kettlebell. into this body weight squat and then up So he's doing a bunch of different variations of it. So he's doing you know, oh look, yeah Yeah, I'm after this podcast Yeah. And it's not necessarily that it's like one compound that's causing all of our problems, as to why so many of us seem to be suffering.

59:24 actually one reason why I think, So the three primary That's one of the reasons, that's actually the mechanism not necessarily causal. There's healthy user bias there. I think obviously people who eat You need these compounds to break down and assimilate fats compounds? Meat is largely absorbed in the small intestine. you know, carnivore dieters say that they poop fine, but I think it's a missed opportunity

1:03:20 Correct. I think that's one of the benefits of fiber. I think fiber has a few benefits. But we know that fiber feeds gut bacteria, I think eating a protein-rich diet. There seems to be many benefits of that and different issues that they've had, it's interesting. as alpha-gal syndrome where people develop a sensitivity to red meat. But by and large,

1:06:14 Yeah, I mean I love I love my steak but and allergies and the like today, which I think is attributed to there are many factors And so I think we have these sensitivities that guy who won that is the greatest grappler of all time. His name is Gordon Ryan. He's People get a lot of staph infections. Yeah, I mean most most people would reach for a probiotic

1:09:14 I think based on my assessment of the literature I'm a huge fan of natto. Raw sauerkraut, raw pickles, you have to make sure that they're raw, you know, not pasteurized. That's rough. What would you recommend to someone like that? There's a, people can Google, like, there's a whole list of, like, it's a low FODMAP diet. It's like nothing's happening.

1:12:00 If that is too restrictive, then I would try maybe a low FODMAP diet. That's like a nice combination. I love it, but uh most of my meals are meat and eggs It's very different. I've ever done. Yeah, you know, I'm like I don't but again you said like there's no like one size fits all It's the most satiating macronutrient. know directly support eye health and brain health. And so I don't see a reason to deprive myself of these greens that I

1:15:38 on salad seems fucking crazy. I hear that all the time. I think one thing that's really interesting is that, you know, even within the nutritional By the way, that's a psyop. The vast majority of saturated fat You know when I tell people that I'm that meat, they're like, what about your cholesterol? It's like to try to walk them that we have become accustomed to.

1:18:40 Like, Jesus Christ. Half of adults today have some degree and actually really unethical. It provides creatine. And yet, there's people that will tell you, And look at, our health is trending But I mean, but it really is a huge problem. And then dairy turns out that, oh my God, wait a minute, it's not low fat and reduced think like insofar as red meat is a nutrient dense, it's very satiating.

1:22:24 you know, my mother had a bias towards Yeah. card around the supermarket aisle, anything with a red heart healthy logo on it would end up in my Crazy. This data hadn't even yet come out yet, but we now see for every 10% increment in ultra processed food consumption diet, those are the things that you should gravitate towards. It's like they are committing a crime against humans.

1:25:20 of ultra processed food consumption. It was all bad. And again, I think it goes back to the to do with the fact that we're not adequately taught. It's never informed consent. That's a new thing. And then they have to deal with all the people around them. that today anybody would would fear monger of, you know, any Mm-hmm. There are lots of tools at people's disposal.

1:28:38 that's a great thing, you know. The more awareness we have, the better. it's it's irreversible at that point So I think the sooner you can get a handle on your risk factors, some of which include And I think humans are, first and foremost, a human is born with zero capacity to survive. I mean, this is not just an emotional phenomenon. With regard to the epidemiology When it, with regard to the, you know, the epidemiology

1:31:36 respiratory fitness particularly in midlife seem to have reduced risk in so just They're carrying you upstairs. I couldn't walk up those stairs Yeah, I mean, it's not a good it's obviously a shitty diagnostic tool So for older people. and adopting them and living them, the better. it's more robust, it can deal with all kinds of things because it's gone through significant

1:35:17 It helps to promote the growth of new neurons, improving insulin sensitivity. Most of it is what is due to what fitness does for my for my brain my brain Totally I think your body telling you like this is you want to exist in certain people that have like really great genes Arnold Schwarzenegger that helped popularize the gym, like that gym culture?

1:38:06 Yeah, and the difference is between I mean there's been a bunch of internet memes about this the difference between like an 80 year grew up drinking tap water. I grew up in New York City. As did I. Yeah, grew up drinking it. used since until the 70s for certain medical applications. and various compounds in tap water that I think, but does the reverse osmosis remove the

1:41:01 These dishwashing pods Gut epithelial barrier damage caused by dishwasher detergent There was something that I read, I believe I read yesterday, because the dose makes the poison and they're very small you know in terms of for a period above that dose, Like broccoli sprouts, yeah. which makes them really difficult to study, and it makes guidelines surrounding them really tricky.

1:44:19 within the field of toxicology surrounding But if you can get a healthy dose with various dosing exposures. And that's one of the problems. When combined with all of the other exposures that your average person, you know and any form of degeneration, whether it's And is it brake dust? whether brake dust or other industrial byproducts And I wondered like if they included Tesla's in those because my I have a Tesla

1:48:06 Because you have to use the brakes if to stop short or something's going on. But for the most What is this? because they're heavier and have more torque, and then the next day, you know, there is blood on your hands and I don't think there's any way to get around it front door to the brain and that's why I think air pollution you know is now very polluted somebody who lives amid serious air pollution probably there are

1:51:17 But certainly when you see that, developing Alzheimer's disease unfortunately in Southern California. I like it accumulates all the shit in the valley. I think I mean there are ways to mitigate exposure. You can damp, you can wet dust. Vacuuming I, is really important. But you know you're breathing in all this other stuff And as an artist, I mean, it was incredibly painful for me

1:54:19 of dementia prevention, which again, reduce risk for dementia. And as I mentioned we you know one of the interviewees that is else. You have decades to set yourself down a different path It's a really intimate look into what dementia is like. that you found that helped your mother and mitigated some of the symptoms? We hired a trainer. And it's just so good for you from a metabolic health standpoint, mental health, brain health,

1:58:31 our hands as we, you know, particularly with the degree of self-harm that your That's a hope. I don't support, risk for Alzheimer's disease. And there have already been a few trials showing that it might improve cognitive function. in cognitive function in patients with Alzheimer's disease, Intranasal insulin, yeah. straight up into the brain, because

2:01:45 that improves cognitive function and there I think they've already I could be wrong but I Was decorative memory rather? Yeah. and requires the awareness of the individual. For example, skeletal muscle, it's not, one of the reasons why semaglutide might help for somebody who's already experiencing cognitive by Biogen because they found it to be effective at reducing the plaque in the brain, but it

2:05:05 condition that has taken decades to develop. particularly earlier on in Alzheimer's disease to generate energy from ketones is unperturbed. What about exogenous ketones? There is one pediatrician, she's a neonatal pediatrician named Dr. Mary Newport who's that when she initially started giving her husband these ketones, And I'm not... coconut oil and she reported a significant improvement and

2:09:28 Um, what other things can be done? University of Finland showing that sauna use is of the world. It's like a shower. It's like one sauna per house and when you're sitting in a sauna. It's a great way to put it. You release a lot of these chemicals that there's a real effect happening there. Yeah. You wanna try to adopt one new habit at a time. some like, you know, that the later in the day we can push our first meal, the better,

2:13:35 And I think that's really important. A bowl of sugar sweetened cereal, coffee with sugar, Try to hit 30, 40, maybe even 50 grams of protein the, you know, down the line. I also think it's really, it can be really know prioritizing whole foods it's like that's like the if there's one dietary engineered. Yeah, it's engineered. the vast majority of our time on this planet, food scarcity was a real issue.

2:16:51 well I think it's 90 days or something like that once it gets to around 90 days Exactly. are friendly, they're nice, you know. I think it's really a shame, because some of the nicest look like that they had to start somewhere yeah to start somewhere and Yeah. The whole ten thousand steps thing is a bit that It's easy. It's not that bad Exactly. Yeah, I just watch a movie just fucking suck just

2:21:57 of tubes and pipes and not every fluid in your body has its own heart. for an extended period of time, Hmm. as they're walking. Very common amongst writers to go for a walk than a 30-minute walk. hour period of sitting? Yeah, not hard, brief, intense bursts of activity, often called exercise and all the talk of kettlebell work. And the way to practice skills is to not be tired.

2:25:10 And at 10 I'm fine, I could totally keep going. I'm not the guy that like goes through these sets like, Alpha brain pre workout that has beta alanine in it a lot of different things. I drink that stuff and If I really want to like for the last set I really want to be fresh and then when I'm hitting these I'm not fatigued Strength. to strength the same way lifting things that are heavier does.

2:28:00 I've never been all that strong. And I want also to be strong functionally. I am, but explain it to people. sure that you're really stretching out that muscle seems to, there seems to be a lot of reward to be gained from that. as opposed to kind of just doing like this Like for example, preacher curls, for example, Is like especially if you have a child fly in your back, this you feel so vulnerable.

2:31:13 but I'm a student of it, of fitness science. And, and I've put it into practice and I've seen some Seems effective. of the exercise, but they're not actually sending with everything in life, unfortunately. Oh man. And so yeah, and so far as I get to provide a you know a more authentic high integrity and grateful to be here, so thanks for having me.

2:34:27 Thank you, brother. Appreciate you And your Instagram and Twitter, what are those addresses?