Joe Rogan Experience #459 — Dr. Rhonda Patrick Transcript

Transcript

0:00 The Joe Rogan Experience. I should give it to you so you could read it. That has a lot of different shit in it. because she had some things to say I have a Ph.D. in biomedical science. And from there, I was like, oh, my God, I freaking love this. And then I decided I wanted to move on with people. And I got a really awesome publication out of it in Nature.

3:45 could help you figure out whether or not a chemical was a mutagen, meaning if it caused By the age of 40, there's a 14-year reduction in their lifespan, Right. And, you know, it's just problems with like using body mass index as a marker for, you know, obesity. It's going to hit the press. So I'm not going to talk about the details of this paper because there's like an embargo

6:22 5-HTP, and then it converts into serotonin. amino acids, they're abundant in protein. So what ends up happening if you're not taking something Yeah. to see what, you know the what the results are what how how not having serotonin in your brain impacts They depleted their tryptophan by that method I just told you about. People don't realize nutrition affects the way your brain works.

9:07 Whoa, no, don't eat gluten. Wheat from the chaff. It's very notorious, you know, in the nutrition field. And there's also the difference between the idea of you just surviving and not getting a disease and you being at optimal health. I mean, that's what's doing everything our body's doing. So cheeseburgers don't give that everything it needs? sun a lot. You know, I know I'm not, I'm always at my computer inside. And when I'm out, we're worried about skin aging if you're a female or skin

13:25 And that's like 30 nanograms per milliliter of the precursor vitamin D called 25-hydroxyvitamin and the less of it can be released into the bloodstream to be then circulated And it's just so worth it. mortality, they've shown that, you know, huge, like, large cohort studies they've done, they've but how few people actually get their blood tested. It's the future, really.

16:53 Like, give us some specifics of what thing. Based on, you know, the National Institute of Medicine doing these surveys, because they were basically saying that multivitamins just those two things were two out of the three tests that they did that they're They pass through people's bowels. I'll read you the three things. the last three months. They didn't measure any, there was no quantitative like biochemical

20:26 effect on the progression of heart disease in heart attack survivors. Again, they're dying. ahead while you're healthy, while you're young. It's so true. I mean, I'll give you an example. So 45% of the U.S. population doesn't have adequate levels of magnesium. And those electron-reducing equivalents are really important because they have hydrogen, which has an electron and a proton.

22:39 species, they react. That's what they do. They react with your DNA. They react with lipids, like in your kidneys and your liver, these cells have a limited lifespan, stuff up. And so, um, in order to prevent that from happening, But you can't look in the mirror and be like, oh, I have DNA damage today. that doesn't pass those checkpoints that usually our genes and, you know, are making sure they

25:20 That's intense. the perfect example is folate. Okay, folate is an essential B vitamin and break in your DNA. And it can do the stuff I was telling you about by causing mutations and leading to cancer eventually. They love folate. I don't understand why they would be motivated to say that based on the findings that they got unless putting out that sort of salacious headline would get people thinking

28:49 they're cofactors for these proteins and what they're doing long-term versus short-term. And I think that may also have something to do with a lot of the MD physicians that were and figure out what all these mechanisms are? what I want to believe and so I'm going to believe it. I think that's another really, you know, Yeah, it seems to me that in order to really get a grasp on what is required, what is necessary for your body, it takes an incredible amount of study.

31:54 but, you know, I want to get it to the people. And I don't want him to stop taking his vitamin because, you know, it's important that he does take his multivitamin. know, that's important when you're doing nutrition research. And that's a really important thing. And Now, when when people take vitamin D, what what is the exact vitamin D they're supposed to take?

34:01 I can tell them what I take, which is 4,000 IUs a day. And when you take vitamins on an empty stomach, if they're not attached to fats and proteins and carbohydrates, do they absorb as easily? See? It's hard to keep up with it. See that thing they said about vitamins? They don't work. And I said, did you read it? And he Yeah. No improvement. And the other thing was he was saying that, what's the vitamin C thing that was getting to me too?

37:57 And I have a unique insight into this because I have some friends that grew up Mormon, and now they abandoned it actually in their 40s. And it's your head and that's his fundamentalism translated to a fundamental skepticism so his skepticism is And from a scientific perspective, that's a really important, it's not black and white. And so people that have that

40:37 i mean and when you talk about uh science being gray of course oftentimes it's not you know but important to make thiamine, you know, nucleotide. It's also important to, But 40% of North Americans have this polymorphism in this gene that doesn't make it work correctly. Well, there's also the variables like how many people grow up and you're in an environment that your biology is not accustomed to.

43:31 Your body adapts to its environment. that person that's had this long-term diet and give them, you know, meat and within 24 hours, and reading on my own about the complexities of it. It actually can contribute to your mood. I feel this, I feel that. Well, let's measure your C-reactive protein levels. Okay. Yeah. Wow. but it lowered their C-reactive

47:14 Absolutely. fucking pollution to a cubicle where you sit and do shit in some fucking shitty macaroni and cheese prevent your shoelaces from fraying. And these telomere lengths, when you're young, they're long. But each time your cell divides, they get shorter and shorter. there's actually an enzyme that can rebuild your telomeres, If you Google vitamin D receptor mice and pull up this image with the, there's mice,

50:12 a supplement that's supposed to, uh, enhance your telomere lengths. I haven't heard of it. Um, supplement. Whoa. Okay, so look, check this out. So those two mice, okay, these are the same age mouse. I mean, there's a lot of things, but look at that. It's pretty striking. And I can measure that clinically. be getting enough vitamin K. But vitamin K is often known for being part of coagulation, being

53:35 And then, you know, two, three decades later, you start to see this calcification in the arteries. or, you know, having your brain work optimally, And they're insidious damage. And we can say, based on looking at these proteins, we can say, But the idea of going to someone who measures your blood and finds out what you're lacking in your diet, that's not normal.

56:35 dose of antipsychotic they were on, the more brain atrophy. And, you know, it's like, so It's so crazy. people. And he quit. He quit taking Propecia and he's starting to feel, you know, like maybe that which is an omega-3 fatty acid. start to have like negative things like hallucinations and paranoia and things like especially in fish oil form. They make such a huge difference in how my joints feel.

1:00:13 eating, you know, they're getting a lot of omega-6 fatty acids too. So yeah, I've seen studies where The shit's going to get confusing. It's pretty awesome. The way you digest it's So lauric acid is 12 carbons. So lauric acid is a 12 carbon medium chain fatty acid. Dude, lauric acid is awesome. the eight chain fatty acids have. Is there an issue with plastic leaching chemicals into things like MCT oil?

1:04:22 Should it be in a metal? to storage to store, that you're, you know, BPA, which can leach into water and stuff. Yeah. this, so, you know, I'm not going to claim to be any expert here, but yeah, they've shown that, Yeah, yeah, yeah. Like I said, I, I don't ever buy MCT oil myself. It's just fat. So when it comes down to, you know, eating a lot of fat, you obviously need fat.

1:07:10 You do need cholesterol. And in order to make bile, to basically be able to absorb them. And you probably have heard of it because in the fitness community, it's sort of like a downstream media or growth hormone. Yeah. They used to allow these guys to fight and they would be fucking these literally Their bodies are so distorted. Very good fighter, though. Actually, some people that are making, when your pituitary makes growth hormone and then stimulates the liver to make IGF-1,

1:11:28 I don't know. Really? And it's also a good thing to go in the sauna when you're not working out, if you're injured, so I can't, a friend of yours, Yeah. all the research that I, that I did to write this article, I'll just talk about my experience. And, I was the other day, I went to a spa and I got a little massage and then they had a jacuzzi There's a lot of things going on, but

1:13:49 because it's just too much. Yeah, a dry sauna. Oh, she's got one of those bags. I've seen those. Is that worthwhile? She looks so stupid. I don't She's pushing it. I've seen those on Amazon, but I was always curious. I thought it was horse shit and voodoo. Okay, so her head's not exposed. to having one of those things in your house I mean, I just went last week to get a massage and just looked at that stupid thing.

1:16:02 You know, I don't know how it does, but they've measured it. But there's an interesting, and I did write a post on this, this tradeoff on growth hormone IGF-1 tradeoff. and you knock out growth hormone receptor, it can live 50% longer. And that's mostly mediated And also in genes that help them take care of proteins and increasing neurotrophic factors.

1:18:37 thereby promoting greater gains in muscle mass and strength. The growth hormone response to amino acid administration has a high degree of Parental. Peritoneal, is that it? Parenteral. God damn it. During exercise, intensity is also a major determinant of growth hormone release, If it says that the administration consistently leads to increasing circulation of growth hormone concentration,

1:21:32 strength or muscle mass to a greater extent than the strength training alone. Because a lot of The guy will lift weights all the time. how you'd have to know exactly who you're doing you'd really have to judge it intensely by the like they're expressing lots of it, I mean, Yeah. It's not making more. But his stomach, that's like apparently one of the things that happens

1:24:50 essentially you're dealing with these chemical projects because that's what they are. They're He looks pregnant. It's very strange. What do you think about... Do you know about all that? Look at that dog. It actually occasionally takes place in human beings. mouse that lives twice as long. I'm pretty sure they live longer. Yeah, there's apparently quite a few studies that have been done,

1:29:46 receptor. And animals lacking myostatin or animals treated with substances that block the activity I do not want to go to school with that kid. He's gonna be the Hulk. Alexander McFerron, who But it does happen in humans. They killed it just to show us its muscle? the fucking you know that's the thing about muscle and it's an issue that comes up in mixed

1:32:46 That's not Photoshopped at all? That's not a myostatin guy. Your mitochondria, when you're exercising, when you're bulking up muscle, you're inducing mitochondrial biogenesis. functional myostatin, but because he is stronger and more muscular than most others his age, Well, it seems like it would help some people if they're, you know, those mice or those dogs, someone's going to take that shit.

1:35:11 and the potential for what they're figuring out these days? be like just a decade, two decades from now? Yeah, I'd like to see some, we've already made lifestyle to try to not get one, but it'd be pretty sweet to have some genetic breakthroughs like specific vitamins or exercise or things like that, the monkey decide what it would eat and then you say, okay, I'm going to give them 30%

1:38:05 but they looked significantly better. That's crazy. So they weren't smaller, It's incredible. And they've seen that caloric restricting actually changes the expression in like thousands of genes. And so it helps like, you know, genes that are involved in, you know, then deal with stress later. So it's kind of like conditioning your body to deal with stress

1:40:40 like exercise is stress and it's a little bit of stress and it does the same thing. So epigenetics is basically causing a change in your gene. they're supposed to do. And other factors can sit on top of them and turn them off. And even though And so that's one study where they've changed the gene expression from caloric restriction. there was a lot of you know there was a great crop harvest um and so particularly this northern part

1:43:22 didn't get to eat as much. the, if they were nine and 12 during the famine years, they had children and grandchildren that lived on average about seven years longer which is like crazy increase in lifespan. And we can't really tell you why, but there's some sort of theories as to why. When you look back at what they used to do for medicine, what we're aware of now.

1:45:59 And so we know this. Oh, yeah. And so they put these mice, usually when we work with mice, And not only did they score better on learning memory tests, they had increased the expression In this case, it was through the egg, through the female line, to the offspring mice, which had the same learning and memory benefits, even though they weren't exposed to that environment.

1:48:34 but epigenetics as well? Right. I mean, certainly, you know, the environment plays a component in those things. But, you know, the epigenetics, we're just sort of starting to understand It's incredible. We're going to make a Dr. Manhattan. making someone's muscle grow like that by like giving them an inhibitor That's what we're going to have. culture and our correlation to, you know, cause and effect and our reactions to each other. I mean,

1:50:53 what's the fucking point? Yeah, yeah. You're too smart to drive. And, you know, then it's like, okay, it's like overload. I had a moment, um, when, uh, my first I'm glad we have that ability to gate out some of that stuff 7 billion people's worth of problems very, very rare in most parts of America, unless you live in a terrible neighborhood, all this horrible shit that's happening,

1:54:43 Right. I mean, they've shown that stress does epigenetically change They're fucking chemtrails. And it's also shortening your telomeres. I eat everything. I eat so much sometimes waitresses don't believe me. two things happen in a day, Right. Oh, I'm sure. And there's got to be a difference between monkeys and human beings, a pretty genes of human beings and the amount of time that we've been in this particular type of a society

1:58:33 I know. that gravity did affect actually genes that are involved in metastasis. And when you culture So, yeah. But then there's also the issue where you can't really go to space for very long anyway. and your body's just so not used to being in gravity and standing on the ground. Yeah. And it does adapt. Which is, again, why it's so infuriating when you read, you know, vitamins don't work, case closed.

2:01:37 I mean, this is science that created all this. You know what those things are? one of these herbal sexual stimulants. They just get like a little fine. So they change the name, you think you're getting, you know, cures, which are mostly nonsense. There's a huge homeopathic industry that's essentially selling I don't know. People like the idea of some exotic thing isolated from somewhere. And it's like,

2:04:54 Nutrition, yeah, nutrition and like this homeopathic... They've given someone a placebo. and maybe that's part of the success of things like homeopathy. make yourself think that something's working incorrect thinking and thinking. Oh, absolutely. I mean, when I started getting, when I started it suggests that we have to some, some control over our cognitive function and

2:07:56 It's affected juvenile delinquency. you've got a population of people that's incarcerated and God knows what they're Why not give them, give their brain the proper nutrients they need to try to heal itself, these... People donate money and we give people these vitamins, these omega-3 and vitamin make sure that these people that can't afford to, you know, eat all these greens and fish every day,

2:11:10 Vitamins aren't that expensive. I mean, relatively speaking, you can, you can get a omega-3 pill, vitamin D pill, multivitamin, and it's not that much money a month. from the well-fed, And I don't know if he's always that good about recognizing when he has done that and correcting himself. coffee through Onnit that was supposed to be the cure to this issue of mycotoxins.

2:13:09 I took too much of this at face value and parroted a lot of the things that he said. and another one called Caveman Coffee. So our friend Tate, who runs Bulletproof Coffee, he tested two bags and And that's where we are with this upgraded coffee thing. You know and made this issue out to be like, If you leave it on the pot and it stays heated, it gets bitter.

2:16:17 You have to. How about that? But the coffee one, they seem to have licked. They know what the fuck it is. They know what causes it. And they know how a formal education in education, in nutrition. This is not something that he's, you know, got a I haven't... Well, it seems like it can What we found is zero. A huge amount of the mold gets killed. And it's like, oh, you can't eat beans because beans have lectins and, and lectins

2:19:41 And actually beans are really high in fiber and fiber gets, you know, It just destroys the mold that causes the mycotoxins. Seem to be bullshit and that's the big one that everyone has mold in their coffee except me coffee. There's nothing wrong with the coffee. that most coffee has mold in it with no fucking evidence whatsoever to back that up. figured out that it's fucking poison i mean i don't know yeah but running around saying that

2:22:27 I fucking read more about coffee over the last three weeks than I've ever wanted to read or thought I would ever have to. across the board think that what he's saying I mean, it's one of those classic examples, you know, create a problem and then offer a solution. There's nothing wrong with it. They're like, if you really cared about coffee, you would let us know when it's roasted.

2:24:26 because I got thrust into this situation. You don't need this. But that guy can fuck with people's heads because he's not an expert. anyone that's a scientist will look at that and go, oh, Pauling and Cameron gave their patients, And a recent study just came out like two weeks ago where they took patients, female patients that had ovarian cancer, which is a pretty good journal for translational research, in fact.

2:27:56 he went and wrote this really distorted thing on his website, fracking. And they pump water in. Theirs wasn't, so gas got into their water. place. Stop this guy right here. these people that have been documented on all these various documentaries, People who have been really made deathly ill those no-nonsense guys. That's such nonsense fucking talk.

2:31:19 then you really need to know what you're talking about He was involved in this eBay scam where they were cookie stuffing. Well, I really think that it has to do with growing up Mormon. and that's how he grew up. If you just Google dangers of fracking, there is a tremendous amount of information out there about fracking, about what's bad about fracking, about the dangers.

2:33:25 I mean, I'm no fracking expert. you know, that doesn't seem like it's good. That seems like that's something that most people are a lot of it is because people have been greased. Don't worry. I liked him. Has he only been on once? think about things. And you're also very open-minded. So it's like, well, what if this is, There is a lot that we don't understand.

2:36:30 So if something comes up and I go, well, is that possible? They want to be that no-nonsense guy that doesn't look like a fool. But the problem is, going to call yourself a science writer for god's sake you know yeah well and the people like that Right. I know a lot about nutrition and science, and there is a hell of a lot that I do not You got to stop doing that.

2:39:02 You know, these people have, there are some good things that they say. this is how it's really happening. And that's kind of what I'm trying to do in some degree. I really do. Found My Fitness. like to host my podcasting. And it's really just to help me continue doing what I'm doing, people like yourself that are actual fucking kick them out. Anything else you want to say to people?

2:42:24 Oh, you do. with a lovely network. of cool people coming in, ladies and Keep it together. We're all in this as one big kiss.