Joe Rogan Experience #672 — Dr. Rhonda Patrick Transcript

Transcript

0:00 And we're live. Hello. Hi. Good to see you again. Great to see you. What's cracking? I've never heard of anybody getting drunk from it. drinking too much like we'd be one of those people that dies from too much water you know how that like very strenuously, like after a marathon or something, and then you drink a bunch of water. Yeah, hazing. Right?

2:24 benefits of the sauna. and I predicted that I thought used it two to three times a week, they had a decrease, a 24% decrease in all cause mortality. sauna. I just actually, the place I'm staying at has a steam shower. So I just had a steam It's like 170 degrees Fahrenheit. with like exercise and sauna use. But the sauna, in addition to that has other effects. So you

5:50 genetic code, it makes RNA, RNA gets translated into proteins, and proteins are doing all the And when you have heat stress and they're activated, they're actually activated for a long period of time. and it increases their lifespan by 15%. So that's pretty cool. that's been shown like in mice, for example, if you make a, you know, a mouse immobile,

8:03 And it's called FOXO3. So FOXO3, it's doing so much. And humans that actually have a variation in this gene. better. So they're able to, for example, you've heard of the paper. It was, the paper was an associative study. So it basically looked at these about 2000 proteins or FOXO3 and other things that are then active for a longer period of time and help you

11:47 chambers because it does create damage, having more oxygen. But it really depends on the context. They use it to heal broken bones quicker, injured tendons, surgery. Yeah. One of the reasons why I brought it up is because there was an article on Joe Namath. But there's two, right? Do they use that? because it was right after I brought you to a UFC.

14:37 doing pretty well. Yeah. And you know, this, this treatment apparently has really helped him quite you know, breathe in more oxygen and, you know, they'repiratory fitness comes into play to people that can, you know, breathe in more oxygen. So that makes sense. as the days go on, as the weeks go by, years, So is there any benefit health-wise to living in a high altitude environment that has low oxygen?

17:44 and train at high altitude. And apparently that's the best combination as far as athletic results. And then you've got to do it that way. produces cytokines right inside I say which are type of protein as well and a memory of something that you learned. It's a memory. And as we age, we lose synapses, And so their scientists were like, whoa, what's going on there?

21:34 And it is able to basically regenerate these synapses because it makes more protein. went down to like 60 degrees Fahrenheit. They exposed them twice and it totally delayed the symptoms. factors that come into play when you're doing a clinical trial like this, where you're having an This damage happens because of the oxygen byproducts, but also inflammatory molecules get made, pro-inflammatory molecules. So, you know, and that's, and that,

25:07 That happens an hour later, and that's happening because of the stress that's induced. damage. And so it's often called overtraining. So in a case like that, and this has been shown Same thing was sort of shown for kayakers that were doing a four-hour boat kayaking ride, which is pretty long. And also if you did it before, it helped mitigate. But another study that you mentioned showed that in people that were doing men that were doing these sort of squats and they were doing leg presses and other like leg exercises when they did cold water immersion immediately after it was it actually prevented muscle hypertrophy or hyper, hyperfuture, I think it's called.

28:25 really hard. They are pushing it to the next level. And those are the ones that are really Growth. well all the studies that were done with beta-carotene that caused cancer were But the other thing is that there are other benefits to doing cryotherapy and to doing cold shock in general. after you know 12 weeks of doing this even after, you know, 12 weeks

31:18 Cognitive dysfunction happens. heat. So you're basically conserving it. And it also is involved in like an analgesic effect. So cool because it's doing really good things in the brain. And it's also got a positive trauma to the head. And I think that, you know, that, that in and of itself, aside from the believe that you actually lose your train of thought I never would have

35:15 better. It's fucking incredible. And one of the things that I found that's amazing is I guess The way I always describe it, I feel like I could jump over cars. they bind on another pharmacologically depleted of it become depressed. And studies have shown, at least, they're not there's a certain half-life, which means norepinephrine is around in your neurons for a

38:04 And also, have you noticed anything with focus and attention? I'm constantly taking, oh, you know, I heard circumnium. and that's usually just a lack of sleep issue or too much exercise issue. But I definitely and it kind of like, it just sort of your body is like, this isn't a matter of dipping our toes in the river. And if there are studies out there,

40:44 So maybe it wasn't. Yeah. Well, they call it whole body because your whole body hard to find so maybe it wasn't yeah well has a great benefit. I mean, I've felt a great benefit from the one that's the neck down as well. they jump into a cold, you know, lake or they take a cold shower. increasing plasma and blood flow to the heart. which are the sites of the energy production, into thinking that.

43:10 And the reason that happens is because you basically want to make more heat when you're cold. like 10 minutes and I go out for like ten minutes at cryotherapy, um, the effects of cryotherapy on rectal temperature, on muscle So when you're in that ice bath for 20 minutes, your's like fucker yeah that's that's probably going to activate that that just came out a couple weeks ago where they looked at the rates of aging in young

45:49 reactive protein, which is a inflammatory mediator. They looked at 18 different things. And then they started getting better. So if they showed their picture to people, random people, and said, guess what age they are, there is a genetic component. There is definitely a genetic component. I was talking about this and what you can do to be that person that looks 10 years younger biologically versus

48:45 disease. And then the second most common thing they die of is cancer. And if you think about in a artery to your heart you have a heart attack if it forms in an artery to your brain you have a How long did they sell trans fats for? It's, they have three years to get it off the shelves. I mean, it's so bad. They know, well, it's LDL cholesterol, and it's not just LDL cholesterol.

51:49 It transports fatty acids and other things. So I think it's easier. to talk about it like that And it does that because every cell in your body needs cholesterol. what HDL does is HDL brings the cholesterol from your cells or from your arteries if it's built up, okay, here's a little piece of cholesterol, here you go. And they're there because they're metabolizing the food you eat,

54:37 In one body. immune cells in your gut. Well, they're separated by what's called the gut barrier. And when that So anytime you're inflamed, you actually increase Like, you know, if you had something stressful happening, wait till you're chilled out and then do another test. released uh it's very damaging and it can i mean endotoxin being released in the system when you

57:32 can't go back to the liver. It's stuck in your circulation. And guess what? Endotoxin is like They secrete all these pro-inflammatory cytokines, which recruit more. cells that are there and how they're being separated by this. It's really, it's called mucin. So your gut cells secrete something called mucin and it looks like they require energy. And your gut likes energy in this form of something

1:00:08 They're going to make sure that it's not breaking down, that your immune cells not coming in contact that's less room for the good stuff, right? The other thing that's happening is that there's actually, and this was shown very recently and it blew my mind, I mean, these are barley. Do you put brown sugar in your oatmeal? The Stevia we had before was, like, almost too strong.

1:02:30 And anything more than that, I would tell people when they were trying it out, like, There's probably some baby powder in there or something. which has 450 billion. Like, so that's like drinking 450 of these. Totally. I would be really worried. Where do you get this stuff? And so I took this for 30 days every day. So it's, like, super cool. How common.

1:05:29 I saw the types of bacteria I had. I had a horrible experience where um this was when i was And so I did this like, you know, three times. So I made a topical cream with a bunch of crazy stuff. it kept coming in the same place I put it on topically and I was taking it orally and literally Right. from, from that, from taking the three rounds of antibiotics. Wow. Because you didn't replenish it

1:08:52 Yeah. How do you feel about taking an SSRI? where I said, wow, you know, these people have no idea what's going on. because I thought there might be a structural defect in like the last part of my colon. Then I can kind of get a little bit of the pain. Personal experience. Don't go politically correct. much information and every time we do a podcast together everyone on twitter says jesus fucking

1:12:21 it was actually joked around. Like I read this criticism of Bill Maher once, the doctor never asked me about my diet? Diet means what are the nutrients you're taking into your system and what is going on with your It seems like you need a whole panel of experts just to figure out how to maximize and optimize like which is the number two cause of death in the United States, but it's been shown to help

1:15:14 And of the ones that do offer it, it's optional for a medical student that's starting their training to take. performance in certain things, cognitive performance, but also can prolong your lifespan. That's something I really enjoy doing. You know, so it helps if you have someone else break it down for them Especially people that are in that massive position of power and expertise.

1:18:05 Maybe he's responding to people just wanting a pill. our gut bacteria is a little different, even though we eat the same diet, you know, we're, survive in that. So they actually die off. So you're like dying, you're killing off this bad like homeostasis thing where it's going between lactate and lactic acid. But one of the things It's like, oh, I'm making too much lactic acid.

1:20:58 thermodynamically favorable, meaning it doesn't require energy to make energy. Lactate goes right you exercise to go into the brain. Preferentially, your neurons actually use lactate, lactate that you're making, the reason you're making it out that basically when you're exercising this lactate that you're That's, you know, like I said, it's very easy to use, so it's great.

1:23:43 And that's for a couple of reasons one is because which is actually the strongest antioxidant in the brain. And it's been like radio labeled where they are able to follow it and show that people when they exercise, it goes right into the brain. gets better. They're walking. So their gait, the way they walk improves. And another study came out Wow, that is crazy.

1:26:40 they're supposed to aid recovery. They're like compression pants. He's fucking nuts. these are compression pants they're for they're for recovery they're um i can't remember the name something like that is that what it says Norma tech yeah that's the one that I I have no idea what's going on there. and see if it has some sort dramatically reduce tightness and soreness,

1:29:38 Damn. How do we know what level of stress and how hard they I think a really good way to do the study would actually be to measure a blood biomarker like IL-1 beta or TNF alpha, which are both pro-inflammatory cytokines, going on in this, this person that's doing training. And I think most people know. It's one of the most brutal things you can do to your muscles, right?

1:32:20 I mean, there's a spectrum of athletes, of how people train. where the pro-stress stuff is going a little out of control. whole, the toughest groups of athletes that compete in mixed martial arts. And I think one whether or not you just have to keep pushing and push through like whatever You're actually causing more damage. there's very few people doing

1:35:38 And would they be better off in some cases doing less? because you're activating a lot of those hormetic signaling pathways and a lot of those have to do with heat shock proteins. Those get activated. Those protect Well, that happens when you're you're doing too much of the stress and then something else stressful happens again. personal trainer, physical trainer. He says measuring your heart rate is a big indicator

1:38:24 He's like, that's nonsense. You got to work out. You know, you gotta, you gotta be tough. You gotta be mentally tough. He's like, that's nonsense. Yeah. um but I do notice that I will I will be more susceptible to getting sick like if I really push me into the sickness But I love that stuff. immune cells they sacrifice you know they sacrifice things and they are basically not getting all the

1:40:27 I think the gut health is indicative of your health status and brain function, as you mentioned. So I have no idea. Even when you're on the road, do you bring it with you? And also when they're prone to activation easily, then the pain stuff happens. And I had both of those. Like I took it. you know, you're, you're wiping out a lot of your, your gut bacteria or microbiome, as it's called,

1:43:45 messing with poop no i i think you know it's been shown in other ways as well timid versus not I don't remember. Maybe there's some studies showing that it can, but I don't think it can. And the other thing is there's a direct line from the gut to the brain. works, but it's doing it. And that's another possible way that certain gut micro, you know,

1:47:10 or even following your heart. Is the heart overlooked when it comes to intelligence? Blah, blah, blah, blah, blah. This is another one. apparent credibility to their off of this. But what I have understood, what I have read, something about neurons, Like, literally, the lymphatic system, you know, is connected to the brain. Okay, this is probably something.

1:50:30 Prominent medical expert, Dr. Maurice Renard and others have discovered that recipients all in the brain you know that it's all in the mind. That seems to be not true. And it I guess it was. Yeah. But what'd you think? I found that it was a very easy way for me to meditate. It's hard for everybody, right? But, you know, there's a lot of brain benefits to meditation that are known.

1:54:11 So meditation's actually been shown to prevent the shortening of telomeres, So the cell machinery goes, okay, well, I've replicated it this far. And then the cell can either undergo cell death And telomerase then, even though the telomere is short, it will rebuild that piece that so meditation isolation tank cold hot gut health all these things you live to a thousand right

1:57:05 It's like, no, I don't want to get cancer, so I'm just going to pop and explode and, you know, die. And until there's like long-term studies done, you know, it's out there. if you already have cancer, it's also not a good idea to supplement with high doses of folic acid. i mean that's cool i mean it maybe when you're 60 you're like fuck it let's roll the dice

1:59:11 And that's the thing that really drives me nuts when they put out these studies. your diet and you're not eating healthy. If you don't think that it has an effect, that optimizing So doing it right varies. It does. And there are so many polymorphisms in genes that affect there's consumer tools available like 23andMe that allow you to, you know, spit in a tube and send it off to this company that

2:01:47 So people that have this form of the gene that converts vitamin D3 into the pre-hormone in greens, you know, and we get it from eating green plants. It's important to make new DNA, It's an antioxidant. in a gene that doesn't allow them to basically metabolize saturated fat as well. And so these people actually, when they go on like a ketogenic diet, instead of losing weight, they actually

2:05:01 and what you can do to kind of overcome this. acids and triglycerides and stuff out of the liver to be transported by cholesterol, LDL, your nutrient, your micronutrient intake and your macronutrient intake based on your own genetic And she's never been able to lower her blood pressure. So it's really kind of exciting for her. So I've been like diving into this recently. And I also have made a free tool on my website where people can export their 23andMe data. And I'm going to allow them to like look at all the genes that I'm interested that I've been researching and finding that are interesting in terms of gene nutrient interactions and ways to come around, bypass that and get around it that you can find coming very, very soon.

2:07:28 I mean, so LDL cholesterol, you know, you make cholesterol in your body. So you can actually make it from having acetyl-CoA, which you can get from even sugar, carbohydrates, glucose. Well, I think that it's, it's more difficult. Travis Barker, very famous drummer. And as long as you take in the right amount, especially like hemp hearts or quinoa or complete

2:09:56 avocados actually increase the absorption of like carotenoids like beta carotene lutein You have to make your blood alkaline. process of oxygen plus the food to make energy. Well, cancer cells, they stopped doing that. So, you know, and that's one of the things when you actually have a cancer cell and you force it it's more likely to kill it. So that's kind of...

2:13:19 And I think this is like, how much research have you done? that's going on in sauna. and then pushing yourself in that really, really hot environment. I fucking hate it while I'm in there. All these things are happening. It's really only one that I've heard of. And, again, it's part of that. and then you're like doing all these poses that you, so you're exerting yourself. So it's absolutely hard and you, you know, your heart rate's going and you're hot.

2:17:15 because it also has performance enhancements. They're able to endure longer periods of, which bind to beta endorphins and to sensitize them. really good. Like if I used it in the morning and I went into the lab, I started using it and I started to notice that I felt really, really good. And I became very interested in the brain effects and the hormonal effects with the sauna and so it's

2:19:28 The only caveat is, and my concern, is that because it is a stress, if you already are stressing your body and then another stress, like, I don't know, surgery seems like it's pretty stressful. So I'm a little hesitant about saying, oh, yeah, just apply it to, like, any recovery. What about cold therapy? Whether or not you should use it right after an injury, you know, I think if your immune system is going out of control, it seemed like it would be good.

2:21:39 Yeah. I mean, that's in my mind, and I'm not an expert on that. about these myostatin inhibited pigs there's uh what are they doing like what are they doing And that is all because of just a gene variance, right? inhibit myostatin, well, then you get rid of that negative inhibitor that's inhibiting muscles from and I want to like either turn it into another,

2:24:17 And when you have a certain gene with it, it'll recognize that sequence when you stick it into the cell. So that's a little different. They're doing it with embryos. To do it with, so if you do it with gene is, and we know what the good one is. Let's give it the good one, send it there, cut out the to make a protein that they don't normally make that can recognize a cancer cell and then kill it.

2:26:37 They're already experimenting with human embryos. it's a blastocyst. and better. because I've been crazy about CRISPR for a while, Just enough to get them to listen code. a sequence of this virus the virus has actually infected the dna i think that that's that's the me, she's a scientist, she thought of this brilliant way to harness that system and use it as a technology to be able to genetically

2:30:38 where that gene is usually and put in a new one and so it's very precise as And this is going to be used for a lot of things. Oh, was it 2012 that they predicted? Yeah, that's what they thought. Well, also interesting to think what's going to happen next. take stem cells and then make the stem cell have a certain, you know, for example, and that leads to cell death. So then you take the stem cells and you make it so that they don't have

2:33:35 So then we'll be able to take a person's own skin cell, make it into a dopaminergic They take, you know, you're going to see. get shoulder surgery eventually but let's just see And they said, well, let's take a look at this in six weeks. And it's also these placental stem cells, they're able to form almost every cell type in the body. Who like so you just what company?

2:36:59 And so that you can like, if you need blood transfusion, you find a donor that matches. stem cell injection and he said literally within less than two months he was healed wow yeah he the environment that it's in. And so different cytokines that are present, you know, in your No pain at all. hurt, everything hurts. Because the whole goal of the art of jiu-jitsu is to damage joints

2:40:21 all those years of getting yanked on like who knows what the fuck's going on in there, but a paper published last February on how important vitamin D and the marine omega-3 fatty acids, Wow. I've seen studies with serotonin. So specifically the paper so they basically suck away all their tryptophan from getting into their brain by giving them this branched chain amino acids, which out-compete tryptophan from they they basically suck away all their triptophan by from getting into their brain

2:43:42 hard for me doing too much seems to be like, it seems to correspond with either irresponsible or impulsive behavior. tryptophan can either get into the brain to make serotonin or it can be converted into something So, but yeah, serotonin totally regulates the impulsive behavior. And so the point that I tried to drive home in that paper was that, you know, people that have these gene polymorphisms

2:46:26 that are as a consequence of having low serotonin. I think that tuning up your vitamin D and omega-3, gotten people that have emailed me and told me that that's helped with their depression and, Too much information. Thanks for having me, Joe. foundmyfitness.com, as well as that new, that genetics tool I was talking about. All right, friends, we'll be back tomorrow with Nick DiPaolo.