Joe Rogan Experience #901 — Dr. Rhonda Patrick Transcript

Transcript

0:00 five four three two one dr ronda patrick hello hello welcome back you got a big fat book of hundred page notebook and it's like a hundred pages of like half of it's the same stuff yeah talk about yeah that would help for comedy reassure people that I'm not making this up because it's so ridiculous. You know, and like one of them was this woman who posed as a high school student.

2:05 oh my god and now he's a felon that is crazy yeah there it is teen falls in love with undercover But if you made something up, like, hey, there was a story in the news and you just made it up. And I'm like, it's so outrageous. Can you do that? on the person yeah i assume everything in your notebook is true well i hope so you know the But if you are learning something and then you run after you learn it and then like the next day you want to remember it so it's more of a longer term

4:45 you know, learning new material throughout the day, then I go for a run in the evening. I've been trying to do yoga three times a week. Yeah. Yeah, that's incredible. gonna be that's been shown like it's been shown like if you part of being a super ager like being You have to push yourself. you do a lot of training, and yet that was still hard for you, you know, because doing that type

8:32 Your brain starts to atrophy at 20? Yes. But like when you start losing mass in your hippocampus, I mean, that's memory learning, you know, that part of the brain. And I don't feel like marathons are my thing. exercise, it activates the part of your brain involved in executive function, which helps you much of that in this life. So when a person is dealing with stress, I think the mind is preparing

11:45 an issue at work that I have to deal with. Like maybe I have to make a decision or maybe, Every 30 seconds, the buzzer will go off. After it's over, I'm like, who cares? fucking boat with a dragon's head at the front of it swinging swords like this is just some nonsense We were meant to be outside either hunting, tilling the land to prepare food, we don't have to eat foods with polyphenols or flavonoids or things that are also slightly

15:14 I have to deal with whatever it is. I just don't necessarily think the body understands where the stress is coming from. I think, Because jujitsu is really, really hard to do. ahead and then you're adjusting those thoughts based on whatever this person that you're You know what I mean? and getting pulled under and drowning and getting tangled with my cord.

19:04 Like, look, there's one on the outside. you'd think that after doing it for so many years that i would get over that fear but Sharks are scary. big wave. Wow. It's in Hawaii. I'm like losing my mind I would say. I mean, the biggest way I've ever surfed is like overhead, you know, like over time and a half overhead. You know, I like to dance on my board and they get in my way.

22:16 in this kelp bed so i remember having nightmares seaweed yes i've had nightmares about it like Yeah, reefs are brutal. should not ever go out on a reef and i've seen many beginners out there but it's yeah it's I served for a long time in La Jolla and there's a breeding ground there for leopard sharks, which are not to be confused with tiger sharks.

23:57 They're not like... You know In the Bay Area It's too scary Yeah Yeah, the sharks. coming to San Diego. New big deal. And Oh, nothing. Don't show me this. Oh, look. Just, I don't know. Are they dangerous? tuna is endangered because tuna are in vastly diminished numbers than they were just a few catch sharks to eat even people that eat meat it's like we're so simplistic in like our protesting

28:39 so compare that to uh wild atlantic salmon which has like four micrograms. Whoa. I actually had an arsenic issue with sardines you have some significant amounts of arsenic in your system. I got some blood work done. And the doctor was like, you have some significant So I backed off. garlic with it. Oh, wow. That's amazing. And salmon is outstanding, too, because it's so high in essential fatty acids, right?

30:58 I'll just break it down to a point where it makes me feel horrible. Yeah, it's spicy. and i went down like this like oh because it was just burning going down i just was like what this I mean, these things are various different polyphenols and compounds. And then once the tissue gets, you know, chopped or whatever, Yes, I have. But, you know, so I've been doing these shakes where you can sprout.

34:28 That's what they're calling it, these kids. I learned that the hard way, thing or if I had too much um okay so I guess I should probably you know it's kind of just like are done to like measure different various brain functions but improve this and this autistic you But it's been shown to be as effective as the antidepressant Prozac in alleviating depression in mice.

37:26 all these brain functions, and why even, you know, someone like me may notice a small effect from shown in multiple studies to be involved in delaying aging. And a lot of that happens through multiple previous studies to play a role in the etiology of those diseases. So I think that's how it may be affecting the brain. But it's not just affecting the brain. And probably one of the most

39:51 But there's the clinical trials, I think, are what's really telling because they're, you know, you're giving someone this compound and it's lowering a tumor progression marker by 86%. So cigarette smokers are like really loaded up with benzene. it was just so significant and a profound of effect just after one day. So that that was another So type 2 diabetics that were given some dose, I think it was something around 40 milligrams as well of sulforaphane.

42:43 animals that's just shown that it like delays aging. So I'm convinced that. And then there's been studies in animals that's just shown that it delays aging. convinced that if I continue taking the sulforaphane I think it will absolutely affect the way I age wrote. Um, and I hope to get published. I think I'm going to submit it for publication because

44:40 sulforaphane like in addition to like what i had already talked about on one of the videos I did and he actually had some really interesting stuff to The precursor, glucoraphanin, is still in that plant. So youexistent the precursor glucoraphanin is still in that plant so so you're by adding the mustard powder. And I was like, that is a really great thing to know. Because now I'm

46:49 And so you would get that benefit plus if you just cooked it and then add the mustard. going to be healthier i think it can help prevent cancer lower inflammation i'm just so many I've seen alfalfa sprouts. shelf and so they're probably likely a little more contaminated with like e coli than if you like six hours and then dump it out and then you just after that you continually just add the water

49:56 Like if your counter's all dirty and your hands are dirty and all the dishware you're using is dirty, then you're probably going to contaminate them. of it. But the thing is, is there's been no and, like, if they actually have what they say they have. And so he actually tested that one. time. And that was also tested. There's another supplement and that is available in the US.

53:11 but not all, you know, and, and the problem is, is that these supplements, I mean, there's a lot and if you're a company that sells that stuff a lot of times you're not even you're not even Oh, yeah, that's true. There's also that. Exactly. It's cost effective. You don't, you don't have to, you know, have extra cash to buy all these expensive supplements because all the ones I just mentioned

55:27 Wow. Awesome. Now, there you go. We actually found better lids that have even smaller holes because some of the seeds were getting out of this. How much maintenance is involved in making these? Four or five days. the longer you wait the more you have to be careful with contamination, too. So it's better probably even to harvest them sooner, freeze them so they're like, you know, no bacteria.

57:42 I mean, that would be a good idea to do. Eleven percent. depression, that were involved in these trials, were people that were severely depressed and hospitalized. were done, starting in the 70s and like 80s, is that the clinical diagnostic manual, it's called the DSM. basically you're getting a bigger group whatever the standard of care is, you know the the initial

1:02:31 depressive disorder, all of a sudden you're getting people that are now like having just, They really have like sexual dysfunction in response to it. Right. I mean, I don't know how many different ones there are. I mean, he's not like the healthiest guy. Well, did you exercise? No. Like, I had a friend who was on Zoloft. You don't feel great. can't like you know you know you can't like excite them or or like make them super anxious either

1:07:16 Yeah. way they're being metabolized. And so if you're adding a drug that's changing the way something's diet lots of refined sugar and that's and that's actually been shown you release endotoxin and it I mean, we're talking about injecting inflammation. So that's kind of, and there's been multiple studies showing this. being shot up with something, you know. So when scientists have

1:11:22 that that was like cut off. The brain was protected from the lymphatic system. But it turns out we were wrong. You know, because that's been shown. Eating a terrible diet does. But the other thing that causes it and it's what you you mentioned, that is a stressful event in someone's life, an emotional event, you know, a breakup, a tragedy, work related stress, social anxiety, whatever it is, anything that causes you to release cortisol, stress hormones.

1:13:15 which then like get in contact with bacteria more inflammation and then it goes back it's like this it makes it seem so irresponsible that 10% of the people are on this drug. with a disease or depression, which I guess you could call a disease. And it just seems so insane They come in because they want a pill most of the time. compared to 30% that respond to placebo, a sugar pill.

1:16:26 I said, an emotional event causes inflammation, doesn't have to be your sugar diet, okay? needed to make different types of immune cells. So your body's like, okay, the tryptophan is going So that's one thing. So that's another way. It's doing a million things. Brain-derived neurotrophic factor, we talked about at the beginning of the competition with branched chain amino acids like leucine and isoleucine. So that's another way.

1:19:08 and taking in scenarios and scenes and events in your life other, you know, dietary lifestyle factors in causing and treating depression. Fuck that. It's an alleviation of stress. in my way. And you know, that that's a lot of times how I look at and it's like you're not that sensory response, that like gut, anxiety, because you experience it. You exercise, you, you know, you, you eat healthy, you experience these things,

1:23:42 some bullshit weights and, but they have an elliptical machine. I go, okay, if this thing has a high setting, I can get a real workout in this. fuck this. I'm out of here. Oh my God. Let me get a donut. You know, give me a coffee. I'm gonna go connected to discomfort like discomfort is your friend it really is like discomfort and and not i know you don't i don't but so many people do i but. Many people, I know you don't, I don't, but so many people do.

1:26:01 It's there with everybody. like push yourself like yeah maybe some people don't have that ability for whatever reason or One of the things that I feel, I almost feel momentum. I think a lot of it is based on just the consistency. It's much weaker and it makes my motivation and my discipline much stronger. that is a pathway that you might choose when it comes to dealing with conflict in your personal life, dealing with business decisions, dealing with career decisions,

1:29:05 I mean, when you I think it's very bad to lie, like even if it's something that is really benign, like what they call a little tiny way. So that's in one of those electrodes that they put on a specific area of the outside of your head and then it's like a you know what? You accomplish something. So it's not only like you're feeling great from all the

1:30:58 It's called Nine Volt Nirvana. they put you in front they give you like a fake gun and they put you in front of a video screen What would you exactly call them? And she went through this 20-minute thing. Right. whole community online where people are talking about experimenting with the voltages and experimenting of a world where anyone with Hold on a second.

1:34:20 at Wright State Research Institute into the studio to tell them how it works. and you blow the fucking engine on the thing, you know? Yeah, fuck it. Yeah. all this junk is in place and the electricity plugs into the back and it's not really variable like you can do shit that you can't do now. You could lift weights you can't lift. You could beat people up. You could do physical fitness fits, feats that, you know, what you right now are

1:37:10 But he looks like he's 50 years older than me. or something like that, a year from now, you would have a completely different body, you know? You could do all that yourself. It's like, it's not just about looking good. It's about aging. Which is really common. explosion dynamite of just bad yeah increasing inflammation i think intelligent people like my friend he is intelligent and i think he connects vanity with those things and he thinks vanity is

1:40:10 I mean, it's not something we grew up knowing, but everybody knows now about your gut biome. Yeah, yeah. You can't stop aging. and they're riding bikes and racing. You're wasting your time. But do you experience this life optimally? I agree. Totally. Totally agree. And I love the way you put it about the feeling good. It's not just about staving off cancer. It's not just about what's going to happen 20, 30 years from now. It's about now. It's about not being depressed. We know that,

1:43:30 Yeah, it's an important concept that I continue to try to get across to people. Have you ever, um, uh, Steven Pressfield has a book called the war of art brought up in And he's like, this is a battle that you will fight for the rest of your life. He wasn't doing well. And, and you're right. It, once you do it, you get better at it next time too. I mean,

1:46:35 there's a lot of stuff that i i enjoy learning you know and so it's something that i like to media as much as i thought but it's definitely blown up in the science so um there's it's so you're fasting in between meals. So like, you know, between breakfast and energy, it requires energy to like have your immune cells be activated and fighting off whatever they think they're fighting off, whether or not it's refined sugar or actual infection.

1:49:50 it's kind of confusing. Anyways, lots of studies on that showing that if you give it to mice that in it. Cucumbers are really high in it. Cabbage is high in it. Edamame. But nicotinamide riboside, Elysium like the Matt Damon movie? Is this a supplement company? N-I-C-O-T-I-N-A-M-I-D-E, like I've met Lenny Guaranty. it's like, it's basically NAD levels rise, it acts as a switch. This rises NAD levels.

1:52:59 were um were performing like 42 better at different endurance activities after being supplemented with this. For like a 160 or 80 pound person, something like that. I don't know. really interesting. And that is terostilbene actually has been shown, again, this is an animal study, to increase the type of bacteria in the gut that causes the conversion of certain compounds, elagitanins, which are found in berries and some nuts, but really high in pomegranate.

1:55:00 autophagy as it's called, which is a cell cell sort of a damaged cell that gets cleared away and eats itself that happens a lot during a fasting state well this mitophagy is doing So, their mitochondria, as you're aging, they're decaying, they're getting damaged and all this stuff. So not only are you getting rid of the damaged pool, you're now creating new ones that are like brand new, healthy, young, brimming, young mitochondria like you had when you were a young person, young child.

1:57:04 Yeah, mitophagy is a very interesting thing. so usually what happens is fasting will selectively, it does. But it all works out perfectly where it's like these enzymes that target it to basically undergo mitophagy, with the blood of young mice and they found that the old mice started behaving the PayPal. isn't he? He does. look at him looks young as fuck he's nine years old he wants to inject himself with young people's

2:00:25 Nick Denton files for personal bankruptcy. which the venture capitalist explains that he's interested in parabiosis, which includes Personal health director to Peter Thiel. So this is actually happening. He's probably measuring all these biomarkers in his blood. but he drinks yes he boozes like every night he was like three in strong at 11 in the morning

2:03:14 I found him to be perplexing. Let me talk about that. Well, just the role that nutrition plays in aging. He didn't think it was a big role. No, he didn't think it was a big role that there was something It's a growth factor 11. and prevent it from like doing its action it's's like, you can stop that from happening. It's not going to be weird if people don't get any older, but it'll be kind of weird.

2:06:06 with like really healthy people. filling that dude up with. Yeah. Yeah. They're injecting him with some kind of young fluid. I don't think he's doing surgery, though. Like, he's got substantially less tone to his muscles, That's also, there's not that much of a variability there. When you look at their telomere length, their telomeres are shorter compared to people that

2:09:08 massive point sugary soft drinks may be linked to accelerated dna aging study so he's i mean sense and i and i do think that there's hope for you know things like genetic engineering and stem and there's a lot of damage that your body goes through. I do 90 pound presses with kettlebells with one shoulder and it's not, I have no pain, no pain, no discomfort.

2:12:11 And usually, placenta are just like thrown away. And I've had some friends. Stem cell therapies, I mean, that's something that I'm extremely excited about for the future. It like has helped me heal like injured wrists. Applied Biologics. And my friend Roddy McGee, Dr. Roddy McGee, is at Total Sports Medicine in Vegas. I know they did that with a woman.

2:15:33 there's like a new clinical study where they're just kind of piloting, you know, doing this Yeah, I'll take it. but now they've started to do it on purpose for mice. out. Like what, you know, cause usually there's some sort of trade-off where you're like, well, Yeah. Right. Oh, okay. That could be a problem. This is 2013 is the one I clicked on. hmm well there's plenty to look at but yeah there it is you can see like the difference in the the

2:18:58 That's exactly what I saw. What is this image? which is double the size of the other mouse. doing anything. You know, people think that like you do steroids, you just get bigger and muscular. Take that fucking off. is like in the the good picture they're tan and the lighting is really good for accentuating muscle too for sure they definitely do that too and um our friend chris bell and uh mark bell who were

2:22:15 What was the guy doing after? Yeah. extend lifespan but there's a point in the podcast where nutrition comes up and um you can tell it That beard is fucking awesome though. but when they talk publicly, talk it down. Like, I don't like that. Like, that's fine if you want And a big factor, too. I mean, I assume he just doesn't just want these super geeks that are all in various ways trying to extend life and aubrey de gray was

2:25:59 What are we doing? I wasn't. Who knows? And that's something that I want to get the message across. They're not. that's extremely interesting. But this like time restricted eating is, it's very important for the day and we sleep at night, which is different from nocturnal creatures like some rodents and because your metabolism enzymes start to go really wrong. Because your metabolism

2:29:58 I interviewed him on my podcast, and he's done a lot of research on this this topic and he did the human study you do that you start to gain more more um fat you start to become more insulin insensitive and So if you're eating that, If they're eating during the day and night, the crap. So you're probably just going to be okay. But if you take that same mouse who's

2:32:25 Like when you first eat and then? He's a big ketogenic diet proponent as well. So he has an app that helps you do that, that actually works really well. Anyways, it's really cool because you can just, like literally these mice were gaining more muscle mass just not by doing anything but eating within this time-restricted window. I'm getting his fasting tracker right now.

2:34:34 That's the time-restricted eating. of coffee because that's interesting because a lot of people don't think that they think that Other than water. Nine hours optimal. That's incredible because I, I eat late at night all the time. So the shells are removed. You know, so you have your social event. But I've been having coffee. We don't have actual empirical data on that

2:38:01 The caffeine starts the clocks. That's perfect. So if you get up and you're at, you know, if you're up at 8 o'clock in the morning or 7 o'clock in the morning, whatever it is, you almost have to eat dinner like at 5. which is most humans. there are people that we're talking about. human data on this, like just looking at the associations between people that eat within an 11-hour period

2:39:50 It's really a powerful thing and improves metabolism, really improves metabolism. And they are there. They're also much more likely to be type two diabetic, So kind of like it says, okay, I'm restarting now because it's late. But still, their fasting blood glucose levels were still on the high end. podcast when we chatted but he is such a phenomenal scientist and he's very proactive and into health

2:42:46 studio. How do you spell his name? Actually, his first name is Sachin Dhananda. knowledge i've i've been following him for a few years like i've really looked up to him for in you and, uh, or your podcast with him rather. Yeah. Check that out. That's a, that sounds which carry cholesterol and fatty acids. in your body, you can't like repair damage as well. You're not going to make as many new cells.

2:46:18 and muscle wasting you know because your muscle is one of those cells you're constantly repairing Well, I mean, you still, you're making cholesterol, you know, in your body and you're making it I mean, I don't know. And it was an internal sugar industry document that was discovered by a researcher at the University of California in San Francisco. But I mean, the thing is.

2:49:16 were handpicked by the Sugar Group of saturated fat because people then obviously started eating more refined like for breakfast And it was so, I mean, it's not just unhealthy. So trans fats are like we have known about the like the fact that trans fats are playing a causal role in heart disease for like decades. It's like, you know, that this is like, it's like so bad so so bad for you um anyways that's a that's a whole that's one of the major repercussions and then

2:52:03 problem is. And that has now been shown in multiple studies. like massively increased for small dense ldl particles and also increased their inflammatory so Ron Krause, he is, he's the guy who actually pioneered this assay and figured out how to And that's just not standard of care. You have to like specifically ask for it, you know? That's so crazy that there's

2:54:41 research and application of it but i mean i don't know what it. But I mean, I don't know what it takes. I'm like, okay, you finally, finally have banned it in the U.S., but you're giving three years? they're not even going to know they're getting it. You blow my mind every time. Um, and actually I just released a podcast today with, uh, Dr.