David Sinclair

Date: 2019-01-29 | Duration: 2h 24m

Episode Overview

David Sinclair dives deep into the science of aging, sharing groundbreaking insights on how the aging process can be slowed, halted, or even reversed. He explains the role of molecules like NAD, resveratrol, and NMN in activating the body’s natural defenses through a process called hormesis, which mimics the benefits of calorie restriction and intermittent fasting. Sinclair emphasizes that aging should be classified as a disease, highlighting ongoing research that targets the root causes of age-related decline rather than just treating symptoms. The conversation also explores Sinclair’s personal health regimen, including his use of supplements, intermittent fasting, and exercise routines designed to optimize longevity. He discusses the potential of emerging therapies such as gene editing and epigenetic reprogramming to restore youthful function, citing promising results in animal models like mice. Sinclair touches on controversial topics like young blood transfusions and the ethical implications of extending human lifespan, while also addressing practical concerns about supplement safety and the challenges of translating lab discoveries into accessible treatments. Throughout the episode, Sinclair shares memorable anecdotes from his scientific journey, including early skepticism from peers and the excitement of witnessing experimental breakthroughs. His candid reflections offer a hopeful yet realistic perspective on the future of longevity science and the possibility of living healthier, longer lives.

About David Sinclair

David Sinclair, Ph.D., A.O., is a leading geneticist and Professor at Harvard Medical School, renowned for his pioneering research on the biology of aging. As co-Director of the Paul F. Glenn Center, he explores the mechanisms behind aging and develops strategies to mitigate its effects, positioning him at the forefront of the anti-aging field. Sinclair's groundbreaking work has garnered him recognition as a global thought leader in longevity science, and he has authored influential publications, including the bestselling book "Lifespan: Why We Age—and Why We Don't Have To." His intriguing insights into the potential to extend human lifespan and enhance healthspan make him a captivating figure in contemporary science.

Key Moments

– Aging
– Longevity Research
– Sirtuins
– Intermittent Fasting
– Supplements
– Epigenetics
– Calorie Restriction
– Metformin
– Exercise Physiology
– Blood Biomarkers
– Genetic Mutations
– CRISPR
– Immune System
– Lyme Disease
– Mitochondrial Function
– NAD+ Molecules
– Hormesis
– DNA Damage
– Animal Cloning
– Scientific Controversy
0:00:19 – Possibility of stopping or reversing aging
0:01:07 – David Sinclair's personal anti-aging practices
0:03:55 – Role of supplements in aging
0:05:07 – Introduction to NMN and resveratrol molecules
0:09:28 – Discussion of mTOR pathway in aging
0:10:09 – Intermittent fasting and meal skipping
0:11:27 – Hormesis and activating body's defenses
0:15:53 – Growth versus longevity trade-offs
0:19:11 – Converting mice biology to human-like aging
0:23:12 – Young blood transfusions and startups
0:24:11 – Classifying aging as a disease
0:27:11 – Health improvements and population growth
0:31:45 – Intermittent fasting benefits on diseases
0:33:55 – Role of the epigenome in gene regulation
0:36:07 – DNA damage from X-rays and sun exposure
0:38:21 – Restoring original genetic information
0:40:46 – Recovering eyesight in mice
0:43:38 – Upcoming safety studies on NMN
0:47:01 – Blood testing to correct health issues
0:48:44 – Exercise routines and fasting
0:51:07 – Weightlifting benefits on bone density
0:52:58 – Risks of tainted supplements in MMA
0:56:32 – Mental training and caffeine effects
1:00:07 – Discussions with Tom Brady's team
1:01:08 – Managing high cholesterol concerns
1:03:00 – Dental procedures and aging
1:06:04 – Maintaining fitness into old age
1:09:20 – Medicines with side effects benefiting overall health
1:11:41 – Choosing HIV for initial testing
1:14:25 – Potential for children to live 200 years
1:16:29 – Advances in gene editing tools
1:18:17 – Speculation about human clones existing
1:19:17 – Cloning of pets and anecdotes
1:22:55 – Iron overload and cellular senescence
1:26:12 – Advice against force feeding children
1:29:16 – Government collaborations on DNA cleaning
1:35:13 – Removing human DNA from blood samples
1:36:04 – Challenges diagnosing Lyme disease
1:59:33 – Documentary on the Sphinx and historical dating

Transcript Excerpt

Starting point is 00:00:00 Here we go. 5, 4, 3, 2, 1. David. Starting point is 00:00:19 The idea that you'll be able to stop aging or even possibly pull it back or at the very least slow it down. Starting point is 00:00:43 What do I do? Starting point is 00:00:50 I wouldn't have thought you were 50. Starting point is 00:01:07 So what are you doing personally? Starting point is 00:01:35 But that seemed to be good because a study came out about a couple of weeks ago, at least in mice, Starting point is 00:02:08 do for us that keep us healthy? Starting point is 00:02:21 Is the idea that you can Starting point is 00:02:39 do you also add them on with intermittent fasting? Starting point is 00:03:01 They live just as long. Starting point is 00:03:35 So it's not an excuse to sit around and just eat chips and watch TV. Starting point is 00:03:55 I also take supplements. Starting point is 00:04:23 And what they do is they protect all organisms on the planet, plants, bacteria, humans, from deterioration and disease. Starting point is 00:05:07 I've heard of resveratrol, but is NMN a new molecule? Starting point is 00:05:27 I feel like I should make a shopping list. Starting point is 00:05:54 what you had when you were 20. So that's not good. And these sirtuins, they don't protect the body Starting point is 00:06:29 I'm not selling anything. Starting point is 00:06:52 Resveratrol is great, but it's really insoluble. Starting point is 00:07:03 I have a few kilos left over from clinical trials in my basement. Starting point is 00:07:26 I do not. Starting point is 00:07:46 even if they have diabetes, Starting point is 00:08:06 Well, I wouldn't call it a sneaky doctor, but the doctor typically has to be convinced Starting point is 00:08:29 In millions of patients around the world, nobody's getting sick. Starting point is 00:09:03 worms to mice and in humans. Starting point is 00:09:28 And then the third one is called mTOR, Starting point is 00:10:09 Well, I try to not eat too much...

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Who was the guest on Joe Rogan Experience #1234?

David Sinclair was the guest on JRE #1234. This page includes the episode overview, topics discussed, and related resources.

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On Joe Rogan Experience #1234 with David Sinclair, topics include Longevity Research, Sirtuins, Intermittent Fasting, and Supplements.

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