Joe Rogan Experience #1234 — David Sinclair Transcript

Transcript

0:00 Here we go. 5, 4, 3, 2, 1. David. The idea that you'll be able to stop aging or even possibly pull it back or at the very least slow it down. What do I do? I wouldn't have thought you were 50. So what are you doing personally? But that seemed to be good because a study came out about a couple of weeks ago, at least in mice, do for us that keep us healthy?

2:21 Is the idea that you can do you also add them on with intermittent fasting? They live just as long. So it's not an excuse to sit around and just eat chips and watch TV. I also take supplements. And what they do is they protect all organisms on the planet, plants, bacteria, humans, from deterioration and disease. I've heard of resveratrol, but is NMN a new molecule?

5:27 I feel like I should make a shopping list. what you had when you were 20. So that's not good. And these sirtuins, they don't protect the body I'm not selling anything. Resveratrol is great, but it's really insoluble. I have a few kilos left over from clinical trials in my basement. I do not. even if they have diabetes, Well, I wouldn't call it a sneaky doctor, but the doctor typically has to be convinced

8:29 In millions of patients around the world, nobody's getting sick. worms to mice and in humans. And then the third one is called mTOR, Well, I try to not eat too much. It's pretty easy to overeat. So I try to skip one or two meals a But generally, I eat normally. Do you ever try going from sauna to cryotherapy? Cool. I do three because I do it all the time.

11:27 And that's really the trick, is to activate your body's defenses against aging. I mean, the old theories about aging, you've got to throw them out. Most people at parties will tell you, oh, antioxidants, free radicals, DNA damage, or mutations. That is all, for the most part, incorrect. Right. We call it hormesis. resveratrol. And so when we ingest that resveratrol from the plants, we get the same health benefits

13:56 Are these epidemiology studies? Right. And you don't want that. You don't want that. So it's the opposite. soma. And our bodies want to do one of two things. We either want to grow really fast and reproduce will live a long time. Like is there a sweet spot? not too much of it but i'm trying to eat as many vegetables especially the the colored ones And we've evolved to sense that, and we get the benefits of longevity as a side effect.

19:11 And so we're slowly but eventually turning a mouse into more like a human So you can have a hibernation of benefits but still live a normal, healthy life. is that you can find mutations, hundreds of them actually, in organisms that lengthen lifespan. But didn't they live longer though? Let's find out if I'm correct first. You just fat shamed. And when you say that fat is bad,

21:54 and they have more muscle tissue and they burn off more fat? And when you say by fuse, you mean by taking the blood of the old mouse and putting it into the What are your thoughts on, if you have any, about the startups that are actually taking the blood of young people and injecting it into the bodies of older folks? What we're trying to do is to treat diseases of aging and even rare

24:11 classified oh i absolutely think aging should be classified as a disease we should think of it as We used to say that about cancer, and we used to say that about dying from an infection. Okay. Well, it is. inability of us to treat people in their old age and keep them healthy How much would the population grow? So let's say it's coming anyway. But what we find is as people are healthier,

27:31 other day that as people become more affluent and society becomes more urban, people will Is that the idea? They got a real problem That's an interesting way of looking at it. And by the way, I used to follow the Okinawa diet. A couple of my good friends wrote a book about it. But I'm getting back there now that my kids are teenagers. And that seems to be the secret.

30:36 I do remember it I might even be wrong about that. they don't overeat. But I've done a good job over the last few years of tapering that off. heart disease, Alzheimer's in a mouse. And so the intermittent fasting is just a way of factors are there that you have The new ones, aren't they like a Well, that's the problem. I was going through a scanner and I said, I don't want to go

33:55 The epigenome is what regulates and reads those genes at the right time. is not that you're losing the DNA structure. So the compact disc information is the genome. So the reader cannot read the right genes at the right time. And I don't know about the scanners, that's just an abundance of caution, but an X-ray will damage your DNA, no question. but being out in the sun also is beneficial.

37:12 No ozone and lack of sunscreen in the 1970s. That would have been convenient. Well, yeah, the ozone layer is fairly important if you don't want to get singed by UV light. But if you have an X-ray, you're going to damage your organs. But what we're working on is how do you get back that original information Are you doing it to yourself already? Take people on death row and turn them into 18-year-olds and go, whoa.

39:22 I agree with you that we want to see what happens in humans. if somebody was blind or almost blind And this is work we're writing up for publication now. increase pressure in the mouse's eye and they lose largely their eyesight and we can recover that. to live next century because it's gonna be even cooler yeah but you're what's cool is you're kind

42:06 we'll see i think there's a chance someone will be well it's it's a good chance you're gonna be but the others like if I had to reading glasses on I gotta do this It's a bit of a struggle. Yeah, I think it's actually... Well, 2020 will be the first safety study, we hope. So when might you need them? Wow. In fact, if you just think NMN is replacing a molecule

45:13 That's the trick with everything in life. Calorie restriction works, but if you overdo it, you also… the day you leave the doctor's office? So the future, and actually partially for those who I have a blood test from a company that tells me what I need to correct. So that's why, one of the reasons I'm on metformin, my blood glucose was going up and up and up

47:57 Where you would notice it is during rigorous exercise. Now, when you are exercising, are you exercising fasted or do you take a certain amount of carbohydrates before you do any kind of physical exercise? Do you structure it? I do now. Just recently got a trainer? Do you set a workout? Do you structure it? It's legal, I think. And during the week, if I have a chance and I'm not traveling, I go to the home gym.

49:42 So I'm not an expert so what i do is i i will spend a half Yeah, but they have handles. It's not like running on hard surface. And as far as weightlifting, what kind of stuff you're doing there because weightlifting does have a beneficial effect on bone density and it What did he say you were doing wrong? It's protecting your spine as well right so you think that's a good plan two to three days a week of weight lifting one to two

52:58 problem in MMA is tainted supplements. People buying supplements and the supplements have other things in them. One a day? Yeah. Wow. Yeah, just to kick of coffee in the morning, but that's it. One a day? Well, I do drink Diet Coke or Pepsi. So you would have to have ungodly amounts of aspartame in order to get these effects That I know. Yeah. Not regularly regularly but yeah that's that's what about other fermented vegetables or anything along those

55:24 So it's almost like you need to keep that pace going. This is the genetics department at Harvard Medical School. And in shape. So part of it could be the mental training that I give myself every day. Caffeine certainly does. I could do with that. No. I don't think anything makes you smarter. I've got dozens of companies. people that have i've been scheduling it or wanting to schedule it putting it off for weeks but uh i'm going to do that soon because i just know too many people that have extreme benefits

59:41 So that's probably a difference. I was just speaking with some members of Tom Brady's team, and they said, David, you've And they're saying you need to drink more. You do. But I have really high cholesterol. Yeah. But I'm a doctor's worst nightmare. I went to the dentist a few months ago, Well, you did my daughter, right, last week. You don't get that?

1:03:00 might snap off or not so you're she's putting a cap on you. Yeah, she's extending my two front teeth. But that's normal. Yeah. I might offer this as a procedure to other patients. I had a similar thing happen with a torn meniscus. I said, look, I'm not a doctor, but that doesn't make any sense. It's totally working. And they're like, well, they told me if I was younger.

1:05:26 Yeah. Their DVD is scratched up. and next thing you know, this guy's an elite marathon runner. really maintained and stayed in the gym and stayed active. And they're regulars at the gym and they look great. You would think that he's 30. It was at 76. hopped up on all these awesome new drugs then you get him working on the He's also on a statin and he exercises.

1:09:20 is that, sure, you can be prescribed this medicine for your Alzheimer's or for your liver disease, but as a side effect, it'll keep the rest of your body healthy as well, Bacteria have an immune system that cuts invaders, cuts their DNA. It's actually, what's interesting about it is we've doing nothing just eating healthy looking good take care bye that's right i'm not gonna tell you

1:11:41 It was weird that he chose HIV as the first test. and it backfired on him because he just did it in secrecy. standard protocol for a scientist whether it is is it the same in china and in russia and in the the radar as best i know and there are countries i'm not going to name them um that are doing I want to be able to travel freely. And eventually, you could kill their child, you know, 40% chance versus one in a thousand. And eventually, you could make a child that could live 200 years.

1:14:55 we would want to have access to what they've learned, right? And that's why we scientists get really upset when companies or organizations don't share information. generation of crisper is that correct uh in terms of uh editing tools, they've become more... They have. Wow. Oh, yeah, it rings a bell. that they're going to be looking into things that are going to enhance athletic performance.

1:17:46 and one of the things that I predicted within the next 15 years There may be some human clones running around right now that we don't know about. there's two of them. A friend of mine, Carlos Bustamante at Stanford we're entertaining the idea of making dogs live longer uh genetically Barbara Streisand had her beloved dog, Samantha, cloned. These are anecdotes.

1:19:59 So that's anecdotal, You know? What is the downside? Do you tell people? hey Dave, what the fuck's going on with your dog, man? My father has all gray hair. Right. excess iron especially in the elderly leads to senescence of cells and build up of those zombie Sure. But for the elderly, overloading them with iron, I think, is a real problem. which hopefully will make sure I'm not deficient in anything.

1:24:29 And I always say, well, I mean, vegetable juice, yeah, it's probably great. But meanwhile, there's just a gang of sugar in that thing. Well, you remember that food pyramid that used to be in the Dr. Seuss books? other thing that that mothers used to and to some extent still tell their kids is don't go hungry And I'm there saying, no, be hungry. No, I'm not hungry.

1:27:02 Well, if you have a child who's overweight These are my own perceptions. All I'm saying is don't force feed a kid. burning so much energy. So you were saying you do things for the government. Before the show started. I just have to make sure it's nothing that's confidential. cleaning a room of DNA, making sure that everything's clean. So I'll give you an example. So the Navy SEALs came up to my lab and they'd like to ask our group to solve some hard problems.

1:31:30 And it destroys all bacterial and viral life. And it wipes it out, and it doesn't hurt humans at all. They scrub them off. Exactly. Like antibiotics is what's created medicine-resistant antibiotic staph infections, right? Yeah, let's do it. the organisms that are there. We can do your It was serious. I'll test it. So this technology can be teamed up with what I've done to be able to get rid of all the human DNA out of a blood sample,

1:35:39 And I know personally maybe 10 people that have it and a couple that have had significant issues with it that have lasted for years. People are getting what seems to be Lyme disease disease and no one knows if it is or not. The first thing we knew- Explain the bullseye. oh so it's um inflammation around the bite of the tick They didn't believe him.

1:37:12 It was really itchy. uh but i don't want to wait a week you know i'm starting to lose my did you get upset with them you say listen you dumb motherfuckers i'm super smart I'd be there for days. And the East Coast of the United States, obviously that's where you live, is just a hotbed. And if you catch it quick enough, does it stop it in its tracks?

1:39:05 Because they left it too long. Those dirty fucking bugs. Uh, It's going to kill everybody. I'm sure. I mean, where was that before? Yeah, and what's interesting is on the skin and in the gut of people in India But these wounds wounds they're actually oh wow is different Yeah. Everything. The little things and the big things. All of it. Wow. hmm much you're so focused on anti anti-aging that having a gigantic workload would seem to me to be

1:43:45 So I guess that's a good test. people don't know about so you your concern is anti-aging you certainly want people to live But what I don't want to do is to be a burden on my kids and my grandkids. called MIB626. What's the other one called? My laundry list. So the company's called Metro Biotech, and it makes super NAD boosters. I got to go to some shady doctor with a weird accent.

1:46:30 We can measure that in their muscles, and we'll test if that worked. Wow. And they have no idea? No idea. Really? They didn't get lactate buildup as much. It was just better blood flow. We even pinched off an artery, and the body responded much better to restoring blood flow, which would be great for patients who have a heart attack. And that's a molecule that's-

1:49:20 skin where i don't have uh any pigment it's genetic my grandmother had it my grandmother's sister had it um i wonder if that would help me uh yeah i really couldn't say what's it called which is too dangerous to try on normal people, that drug has been tried on elderly people and it boosted their immune system in the same way that you see with calorie-restricted mice.

1:50:50 Can I look better? They don't just live longer. inside tracker looking at blood biomarkers but there's a new one called the dna clock Wow. things it would be really fascinating if you could document that you could take one person But yeah, we call it longevity research. especially with men. Right, right. Exactly. You are a weird – you're not allowed in the club of advanced species.

1:55:20 But they'd be like, why didn't you just get it and then just wash it off or something? So in terms of leading labs, there's about 20, 30. But it's a big field now. Like, a lot of my friends, my supervisor said Lenny Guarente's lab, two students had just started working to figure out why yeast get old. Yeah, but that's an interesting one, right? Because you were a young fellow.

1:58:04 Drunk? No, I definitely forgive people too much. fuck face i was right no you don't call them up in the middle of the night drunk no i definitely Thomas Kuhn's book on the structure of scientific revolutions oh, no, people are saying we're wrong, and it's controversial. We don't want to be controversial. I'm like, controversy is great. Yeah, there's an amazing documentary on the Sphinx

1:59:54 Because apparently it would have predated the known dates of 2500 BC, And he's showing it, and he even showed it to a bunch of other geologists, Yeah, kind of have to. They don't look at it that way, though. Change over time. this is what they talk about this is what they study when i found out that scientists would Call them up, you dumb motherfucker, have a couple of glasses of wine

2:03:40 right? Sure. You have to entertain the possibility that you're wrong. That's Yeah, bad luck. It's just discouraging from a non-scientist who relies on people like you. But they were wrong. Call them up, middle of the night, you dumb motherfucker. And what was the high? moved into your favor yeah there was there was. There was one day when it all changed.

2:06:51 And now we have a mouse that doesn't work. the very brave student, if the change in that enzyme also blocks the drug, Resveratrol works. Right. He was dead against me in my own lab. if you build up too many enemies, you won't survive. was to get here and how fortunate I am to have made it this far. Well, it's a little company that we bought in New York and nurses and dentists use

2:10:37 whether it's deserved or not, So I don't sell any supplements. these molecules without someone accusing me of doing it for a profit that's what i would think Well, I've made a fair amount of money in my life. as chairman, vice chairman. If you go to my lab's website, you'll see everything that I do thing that I want everybody to know is in the lab, we do very basic research. We try to understand

2:14:13 everything you can before that to make sure it's not going to be unsafe, testing it on cells It takes one to two years. It's hard. Yeah, but how much would something like – you'd have to sell it for so much money to make up for all the research money, right? what's right for the planet so when you do do that um how will you decide how much something costs

2:16:51 Yeah, that guy. and it's been proven that there are certain unscrupulous drug companies It's harder than going with a pitch to a capitalist, Help the world. 2104 that stuff where would one get that that's experimental that's probably where would one get that? That's experimental. That's probably the hardest one to help you with. I mean, they're a few thousand bucks to your whole genome.

2:19:43 and I'm carrying cystic fibrosis gene and whatever. go to the doctor. Harvard website come out later this year that's it bye everybody Come on back. Would love to. Give you an update. Thank you, David. Really, really appreciate it.