David Sinclair

Date: 2019-09-10 | Duration: 2h 22m

Episode Overview

David Sinclair dives deep into the science of aging, exploring groundbreaking research on how biological clocks can be reversed. He discusses the epigenetic clock developed by Steve Horvath, which measures biological age and how recent studies suggest it can be turned back by a decade or more through specific interventions. Sinclair explains the role of molecules like NAD and compounds such as resveratrol in activating sirtuins—proteins that defend against cellular aging—and shares insights on how these pathways influence longevity and physical performance. The conversation also touches on lifestyle factors, including exercise, diet, and intermittent fasting, that support healthy aging. Sinclair recounts personal anecdotes about his own health experiments and the importance of goal setting and recovery. He reflects on emerging therapies like senolytics, which target senescent cells to rejuvenate tissues, and gene editing technologies such as CRISPR, highlighting their potential to treat age-related diseases and regenerate organs, including the eye. Throughout, Sinclair balances optimism about future medical advances with practical advice on maintaining vitality today, offering a compelling look at how science is reshaping our understanding of lifespan and healthspan.

About David Sinclair

David Sinclair, Ph.D., A.O., is a leading geneticist and Professor at Harvard Medical School, renowned for his pioneering research on the biology of aging. As co-Director of the Paul F. Glenn Center, he explores the mechanisms behind aging and develops strategies to mitigate its effects, positioning him at the forefront of the anti-aging field. Sinclair's groundbreaking work has garnered him recognition as a global thought leader in longevity science, and he has authored influential publications, including the bestselling book "Lifespan: Why We Age—and Why We Don't Have To." His intriguing insights into the potential to extend human lifespan and enhance healthspan make him a captivating figure in contemporary science.

Key Moments

– Longevity Research
– Sirtuins
– NAD Metabolism
– Resveratrol
– Mitochondrial Function
– Exercise Physiology
– Senolytics
– Genetic Engineering
– CRISPR Technology
– Stem Cell Therapy
– Aging Mechanisms
– Nutrition Science
– Microbiome Health
– Sleep Optimization
– Climate Change Impact
– Human Evolution
– Wildlife Conservation
– Mental Health
– Biohacking
– Exosome Therapy
0:00:00 – Introduction to David Sinclair and his research
0:02:50 – Discussion on biological age versus chronological age
0:05:31 – Resveratrol's role as an antioxidant and sirtuin activator
0:07:33 – Importance of NAD for sirtuin function
0:09:10 – Effects of NAD on physical performance in athletes
0:11:51 – Mitochondrial biogenesis triggered by energy demand
0:13:23 – Conversation about causes of diseases and lifestyle
0:17:25 – Impact of alcohol consumption on health
0:19:04 – Wildlife encounters and natural living insights
0:23:39 – Challenges faced by indigenous peoples and natural lifestyles
0:28:51 – Dental health and regenerative medicine
0:34:19 – Experiences and reflections from Serengeti safari
0:38:28 – Human evolution and ancestral origins
0:48:48 – Longest lived humans and genetics of longevity
0:50:22 – Discussion on smoking and longevity anecdotes
0:55:36 – Nutritional value of human bodies and food waste
0:58:15 – Concerns about climate change and human capital
1:03:00 – Importance of goal setting for healthy aging
1:11:21 – Benefits of intermittent fasting
1:14:03 – Apple Watch 5 and personalized health tracking
1:15:49 – Differences between NMN and IV NAD treatments
1:20:44 – Homemade yogurt and microbiome health
1:32:12 – How resveratrol activates cellular defenses
1:37:34 – Anthony Bourdain's diet and statin use
1:41:56 – Use of melatonin for sleep optimization
1:46:56 – Radiation exposure from travel and prevention strategies
1:50:22 – Potential of CRISPR for genetic alterations
1:56:11 – Stem cells for organ and blood cell regeneration
2:00:47 – FDA approval pathways for eye disease treatments
2:05:24 – Skin rejuvenation using stem cells and exosomes
2:13:00 – Senolytics and clearing senescent cells
2:19:05 – Summary of lifespan extension and aging prevention

Transcript Excerpt

Starting point is 00:00:00 David Sinclair Starting point is 00:00:16 Yeah, well I don't know anybody who does Starting point is 00:00:34 like within the last couple of days that was going around through all the mainstream papers. Starting point is 00:01:02 That's what I'm looking for. Starting point is 00:01:19 Schmoes, yeah, which is good news for schmoes like me. Starting point is 00:01:41 Anyway, the guy there, Steve Horvath is his name. He and I Starting point is 00:02:18 It's something brand new. Starting point is 00:02:50 you are, okay, you're 52. You might be 46, according to that clock. And also I could Starting point is 00:03:22 Are there other ways of going about it? Starting point is 00:03:54 turn the clock back by a decade or more. Whoa. Now, what things are you talking about that could Starting point is 00:04:57 time changes. That's what I think is going on. Starting point is 00:05:31 Resveratrol was originally thought to be an antioxidant, and it is a mild antioxidant. Starting point is 00:06:01 Yep, a teaspoon. Starting point is 00:06:39 okay yeah that's great but it has to have something to bind to is that the deal for sure yeah in in Starting point is 00:07:05 If you read the paper, and I have, Starting point is 00:07:33 NAD is required for the sirtuin defenders to work. Starting point is 00:08:04 It could. Starting point is 00:08:26 to my friend, Steve Horvath, nine patients, are you kidding me? Why didn't you do 50? And they Starting point is 00:09:10 it actually decreases physical performance in athletes. Starting point is 00:09:40 I mean, some people have been on this show, run 100 miles every weekend. Starting point is 00:10:24 best guess is that we want to allow the body to recover. So I don't actually know what the best thing is. But my best Starting point is 00:10:52 It's pretty natural. Starting point is 00:11:13 Without that chemical energy, we'd be dead in about 20 seconds. Starting point is 00:11:51 running out of energy the body respond...

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Who was the guest on Joe Rogan Experience #1349?

David Sinclair was the guest on JRE #1349. This page includes the episode overview, topics discussed, and related resources.

What topics were discussed on JRE #1349?

On Joe Rogan Experience #1349 with David Sinclair, topics include Longevity Research, Sirtuins, NAD Metabolism, and Resveratrol.

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The full searchable transcript for Joe Rogan Experience #1349 with David Sinclair is available on this page, along with key topics and timestamps.