Joe Rogan Experience #1349 — David Sinclair Transcript

Transcript

0:00 David Sinclair Yeah, well I don't know anybody who does like within the last couple of days that was going around through all the mainstream papers. That's what I'm looking for. Schmoes, yeah, which is good news for schmoes like me. Anyway, the guy there, Steve Horvath is his name. He and I It's something brand new. you are, okay, you're 52. You might be 46, according to that clock. And also I could

3:22 Are there other ways of going about it? turn the clock back by a decade or more. Whoa. Now, what things are you talking about that could time changes. That's what I think is going on. Resveratrol was originally thought to be an antioxidant, and it is a mild antioxidant. Yep, a teaspoon. okay yeah that's great but it has to have something to bind to is that the deal for sure yeah in in

7:05 If you read the paper, and I have, NAD is required for the sirtuin defenders to work. It could. to my friend, Steve Horvath, nine patients, are you kidding me? Why didn't you do 50? And they it actually decreases physical performance in athletes. I mean, some people have been on this show, run 100 miles every weekend. best guess is that we want to allow the body to recover. So I don't actually know what the best thing is. But my best

10:52 It's pretty natural. Without that chemical energy, we'd be dead in about 20 seconds. running out of energy the body responds and makes more mitochondria just like exercise does And I think they measured a bit of strength. We don't know exactly what that is. That's what I'm saying. One day, three hours? Like I had Peter Hotez on the podcast. What's the number one cause of diseases?

14:05 they just can't get it together well i would work out more if i had time i'm usually working Yeah, that was fantastic. Yeah, you want to do it again? Today, if you have time. Yes, I do. It's fantastic. It's very nice. You don't need a machine either. He's 50-something now. my apologies because I was coughing like that You can push it a little too far sometimes.

17:25 i've got to lay off the booze yeah well how much do you drink uh i'd probably have one or two a day You know, like, all right, now it's time to get serious. We did also some hiking. Yeah. I didn't realize it was a mountain lion unnerving. Grizzly bears are without getting eaten yes yeah we don't think about it that way because we're so used to being

20:12 What, you were born with a toothbrush in your hand? None of that's natural out of other dimensions sure all the drugs They'd go kill one of those elephants in the jungle. They can't anymore? parasite that is uh just devastating his health he's trying to figure out what it is. Yeah. He's a huge man to natural way of life but you're a good man joe for uh supporting the the pygmies i was just in

23:12 Oh gosh, but they need help They've got everything they knew how to live is gone. I guess. Natural. there's just this constant cycle going on and you're walking around yeah now when you walk Yeah, it's interesting. Did you see it catch it? and dragged them out you're kidding no that's the worst way to go yeah it's the hyenas you It got away from the croc.

26:41 It was a solemn moment. I think it was a few, but... The Jeep and the people in the back of the Jeep. You know, you can see it on BBC or whatever as much as you want, and they found the cat on top of the elk. We saw a lot of those. and give them some implants? They do it with people, right? They fixed my daughter's teeth. Because they feel like you're on your way out exactly yeah someone said that to me in terms of uh meniscus i had a meniscus tear and they said well when

29:37 Like is blood not flowing? For sure they do. I think if I wanted to go on safari like that, like you did, I would have to make sure that I wasn't around any cheering assholes like that. I bring the Elon Musk flamethrower with me and crash-landed in these lion-infested territories? He got. But meanwhile, he was getting room service and eating steaks and shit.

32:00 And so he has a limited amount of propane. He would hear He'd be like oh fuck time to fire it up again and so he was out there sleeping in this basket It's beautiful. that want to do stupid shit. Two nephews, and my kids are 16, 14, 12. Perfect age for this. Did it fuck with you? Oh, wow. Yeah, Serengeti was incredible. Wow. Wow. because i watched it for hours i just sat there in my room drinking a cocktail with my feet up

36:27 this is a sacred object, this is a sacred place, we're going to wear sacred clothes, How would you say that? So it is actually a meteorite, which how incredible, right? hanging out. No one really cares. Admittedly, it is out of the way. It's not in the middle of the Middle East. But still, it struck me that But it is that the idea that a human being came from some lower hominid, which came originally from a shrew, is so, so hard to follow.

38:59 Yeah. I mean, they go out to Australopithecus, explain Australopithecus, explain the various other human beings, explain Homo floriensis, explain the Neanderthal, explain all these different. are no good listen let's get a taller skinnier one but with bigger brains aha right and let's Find out if that's, is it Kyrgyzstan? Silency. But the fact that you could kidnap someone

41:10 I couldn't help myself. Is this ordained? That's like grass. We're just looking at low resolution. wall you got it yeah james gonna pull it up so make it to the top of the wall. You got it? Yeah, Jamie's going to pull it up. Maybe. movie yeah who wrote that movie it's a wild movie man this is it's one of those um zombie movies shuffling towards you.

43:43 because people are going to say, Shout out to Max Brooks Are we done talking about Africa? I recommend everybody go to Africa, not just to come back a different person, a better human being, but also to support them. hurry, hurry, we have to go see some zebras. Yeah. Tell me later. she found a whole bunch of stone tools. 16 000 years ago the oldest known stone tools of any human being and it's sort of they're

46:42 chimps i just sat across and watched the chimp cage. It was just wailing. Engineering. Are clothes unnatural? and I said, that can't be true. 122 is the longest lived human that ostensibly is on record. There's one called FOXO3 that if you've done your genome, we can have a look. three have both. So if they look after themselves, might have a better chance of living longer.

49:55 And they live another 12 years? And she said, all four doctors I went to told me to quit smoking, and they've all died. Yeah. You seem pretty healthy to me. Wow. And she made it to 122. Now, have there been any anecdotal reports of people that lived longer? Oh, really? So there's a lot of forensics going on and people want to subsume the grave. I would say it doesn't actually matter.

52:30 Well, my dad's experimenting on himself. That's embarrassing. I shouldn't do that. Last 10 years of her life, horrible. Whoops. aging. Adults ruin everything. What was her advice? Like in terms of like, why, how do you avoid Make sure that you leave this place better than you found it. Down to your knees? I think so. What did they look like? Maybe it was a one piece.

55:36 Wow. and that human bodies are very nutritious and that we just put them in the ground. Because we throw away half our food anyway, at least in this country. It is meat, but come on. and if they want to eat meat, they should eat human meat because it's going to waste. Speaking of the food supply, one of the things people worry about if we all live longer is

58:15 You think climate change, we're going to be able to engineer our way out of that? And there's only a certain amount of human capital one of them is to solve what are we going to do with all the frail elderly people I'm not sure of his protocol Yeah, the guy's a phenomenon. What has happened, though, is that his outlook on life has changed. So just a few years ago, he went back and started a new career.

1:01:05 Be excited about something as well. mistakes i'm more aware just across the board and i'm wiser at 42 than i was at 32 and at 22 i was To me, it takes a big hit when I'm lazy. One of the things that seems to be most important is goal setting. And anyone who's listening who's in their 20s and thinks that they're way better than a 50-year-old, Right.

1:04:36 Yeah, that's what's crazy about it. right so so in the future 90 will 90 will feel like 50 and well we were talking about laird And it's going to be such a great world when people with 80 years of experience I have to polish back your original teeth. Yeah, she's trying to make money. But here's the problem with some aspects of medicine. and might extend your lifespan. Where are you getting a cup of coffee for a buck i get free coffee from here from laird hamilton

1:07:54 Six months later, it'll be done. Let's be honest. Well, they were. No, actually, this is the problem with the other end of the spectrum, which is I was too young to get a medicine that could help me when I get older. But do you have arterial plaque? Do you have the appropriate ratio or is it out of whack? Yeah. Yeah, as much as I can. Yeah, like the coffee.

1:11:00 I go through them in my book because we won't have time to go through all of it. Be hungry for part of the day. of a rat was actually discovered back in the early 20th century will make them live up to 30% longer, not in an old state, but it prevents them getting old. So the rats don't always have to be on a treadmill. You know, now that I'm 50, I have a pretty good, like, you know,

1:13:25 O-U-R-A. Jamie says yeah. How dare you? I go there every day because real interesting stories on the internet. By the way, they just released Apple Watch 5 today. Apparently it's better. You might want to get it. What does it do? What Personalized So you just have a look, like, what your resting heart rate is, how much activity, how far you're walking, how many calories you're burning, that kind of deal?

1:15:24 Well, we don't know. Now, what is the difference between the effects of NMN and IV NAD, which is very popular? publicly that I've done it It was fine. This doctor is experimenting. But here's the thing. Now, there are a lot of people that swear by the IV version of NAD. especially down in Florida, to treat addiction. Right. I can't. like how much time did you study nutrition this is nonsense talk you can get everything from a

1:19:17 There's so many doctors that go through their entire medical, orthopedic surgeons or what have you. Plus they have to work within the insurance system. and eat a lot of grain. It just makes sense that it's got all the enzymes in it. But the benefits in the taste and how I feel, that yogurt, I make myself out of whole milk. You got one of them churners?

1:21:13 I got so hooked on this type of yogurt, which I first made for my son, trying to help him. There's three different packets. 95. Okay. Yeah, so far. and this is a company that makes a yogurt that matches a healthy microbiome. Like a health food store, like Sprouts or something like that. and then think about people buying whole milk, It stays on the shelf longer.

1:24:31 But isn't spoiled milk yogurt, ultimately? By the way, when we had chickens, we were these nasty coyotes that killed all my chickens, agents who who are these assholes that are getting paid government money from our taxes to steal whether there's a way to test I don't know what made it. Now that I think about it, it's both. Yeah, that's good. have more complex glutens and higher yield like we do so we don't buy bread in my family my wife

1:27:39 Well, he put some wet dough up in a tree and left it there for a few days and caught this wild yeast up in the One of the things that I've heard about the French and Italians in general is that they eat their bread with either butter or olive oil. And actually, I asked her, what's the worst food you've seen in your body to spike glucose? She was 99 of my nutrition knowledge i get from ronda patrick um but i believe it's something to do with the way the potato reacts

1:30:13 That's the other 1% of my nutrition knowledge. Blah, blah, blah, blah, blah, blah, blah. Right here. our gut biome and the subsequent metabolic benefits cannot be overstated. I've seen this So resveratrol comes on when – Well, I'm glad you asked. So we have this I think we're attracted to it because they're colorful. But what our bodies get out of it is that these chemicals go into our bloodstream and they turn on our defenses against disease to survive.

1:33:47 They're giving us this stress heads up. Quercetin, which is good for a number of things. Is this apparent in red wine? I'm like, that's for chicks, bro. like the negative aspects of eating shitty food? And what kind of dose were you giving these mice? Right. mice, carefully put them to sleep for scientific purposes. It was clear that they were healthier.

1:36:42 If you are fairly convinced because the research of the A little bit. interesting because um bourdain when he was alive um he had made a decision to take statins versus change his diet. I know they're dangerous. He quit that, and then jujitsu became his new addiction. Yeah you should I could have gone off them And tofu. I'm not going to. I don't think is sufficient to keep these cholesterol levels down. So combination so far.

1:40:35 Like I said, you look good. When it starts slipping away, what are you going to do? Yeah. Oh, that's good. you know, now people say, which is massive i nibble on it i take maybe a milligram just to nod off if i'm desperate with For me, because I'm monitoring it, I know that I'm getting good deep sleep. Wear the glasses. Really. Need to get those, huh?

1:43:41 Yeah. Right. Do you get that seasonal affective disorder? to la and it's blue sky you really feel different for sure. There's a reason why there's a fucking billion people out here. Make a difference. Yeah, a lot of people get fat in the winter too. is shortening your lifespan by making it easier This sounds probably pretty boring, but I'll say it again.

1:46:56 X-rays will do that. So when you go through that radio scanner, then the more modern TSA scanners, they give you the same amount of radiation as a flight? What's it doing to you? So when I'm on a flight, I take some NMN in the expectation that it's going to boost my body's ability to prevent those changes to the lifespan why we age and why we don't have to

1:49:34 Just to get the facts straight, I don't sell anything. riboside, which is also what the body can use to boost NAD levels. And that's a little bit cheaper. And that's also be honest. We know what's going to happen if we don't do anything, and that's not pretty either. Do you have any high hopes for things like CRISPR, things where there's going to be genetic alterations?

1:50:52 Now, right now— Can you explain it to people who don't know what it means? can also use it to cut the genome and insert new pieces. So you can both subtract and add like four or five times just try to figure out what the fuck they were saying am i making any Let's say, why not mutate what's called PSK9 Did it mess with other genes? It'd be outlawed.

1:54:14 There is the fear that some country is going to engineer an army of clones. Really? Dude, my eyes are gone. I can barely read print on a laptop. I need glasses to read my laptop. You're going to lose your job Any time in our lifetime? These are cells that can be used to make new organs or new blood cells. But what people hadn't You put them in the eye.

1:57:03 So what is the company again, Jamie? Look up this. and they'll try something experimental? That was the idea that people were, the resistance to malaria, That Lux Turner stuff, is this something that someone like me could take right now? so they're using this for and these are benign viruses We don't know yet. And the doctor says, come back in a couple of decades.

2:00:20 The vision thing, do you think that we're going to see that in our lifetimes? First of all, we have to go into an area where it's FDA-approvable, which is a disease like glaucoma, which is pressure in the eye, or macular degeneration. But people with eye injuries? right eye is extremely poor. Shout out to Michael Bisping. Do you think that that's something that inside of his lifetime they could see something, the use of this technology that could regenerate his eye?

2:02:15 and people walking again. are you anticipating for bringing this to When we first discovered this, the experiment was to have a fresh injury, the pinching of the He said, David, you won't believe it. We haven't tried old injuries. Very limited in one eye. Crazy. you could look at that retina to people's skin? Yeah, we're going to try it on aging on the skin.

2:05:58 Now, that doesn't prove wrinkles, but it does prove the skin can be rejuvenated as well. I didn't realize people get it all over their face. And you get rejuvenation. Yes, well, it's a weird thing, the exosomes and stem cells, Yeah. Yes. I'm glad you brought up the study of the old mice and the young mice, and said, stop it. That's it? I do not remember the name of it, but I remember they were erroneously linked to Peter Thiel,

2:09:48 so you get a bunch of young people that are healthy, disease-free, Come on. I missed the boat. Yeah. He's like, oh, you got a crack. He saw it from like where you are, like looking at the phone. It's just plasma. Doctors behind failed anti-aging blood clinic tries again would you like to do studies on people that are doing that and find out i mean well what they

2:12:35 I try. Yeah, there's something that is really interesting, and that's called senolytics. Now, senescent cells are pretty rare. is messing up the cell's ability to be what it used to be. What do I mean by that? Let's take your eye. I'm not a skin cell. And that's another treatment like reprogramming that could be a one-shot delivery and take you back a decade.

2:16:08 Wow. Yeah. We've got – I've got to include all sexes now. She didn't think that was appropriate. Yeah, she changed it at 11. That's hilarious. Yes. True. This is amazing, man. It's really interesting, man. Lifespan, why we age and why we don't have to.