Dom D'Agostino

Date: 2017-08-07 | Duration: 2h 57m

Episode Overview

Dom D’Agostino dives deep into the science and practical applications of the ketogenic diet, highlighting its therapeutic potential beyond weight loss. He discusses how ketosis can serve as a metabolic therapy for neurological disorders like epilepsy and ALS, explaining the diet’s ability to shift the brain’s fuel source from glucose to ketones. Dom shares compelling research showing how ketogenic protocols can silence disease pathology and improve motor function, particularly in genetic conditions. He also touches on the use of ketone supplements to elevate blood ketone levels and enhance brain energy production, offering insights into their role in managing seizures and neuroinflammation. The conversation also explores the challenges and nuances of maintaining ketosis, including the impact of protein intake and the importance of tracking macros accurately. Dom reflects on his personal experience with intermittent fasting and ketogenic dieting, emphasizing the mental clarity and sustained energy benefits he observed. Additionally, he addresses misconceptions about carbohydrate needs for athletes and discusses strategies for integrating low-carb nutrition with performance goals. Throughout, Dom underscores the broader implications of ketogenic nutrition for chronic disease management, cancer therapy, and longevity, supported by ongoing clinical trials and emerging scientific evidence.

About Dom D'Agostino

Dr. Dom D'Agostino is an esteemed assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, as well as a senior research scientist at the Institute for Human and Machine Cognition (IHMC). Renowned for his pioneering research in ketogenic diets and their applications in health and performance, he has made significant contributions to understanding metabolic therapies for neurological disorders and cancer. Recently, he was a crew member of NASA's NEEMO 22 project, where he explored the effects of extreme environments on human physiology. A sought-after speaker and expert in metabolic science, Dr. D'Agostino captivates audiences with his insights into the intersection of diet, health, and human potential.

Key Moments

– Ketogenic Diet
– Metabolic Therapy
– Ketone Supplements
– Epilepsy Treatment
– Cancer Metabolism
– Intermittent Fasting
– Mitochondrial Function
– Neuroprotection
– Blood Glucose Regulation
– Wound Healing
– Athletic Performance
– Nutritional Biochemistry
– Pet Nutrition
– Exogenous Ketones
– Diabetes Management
– Neuroinflammation
– Hyperbaric Oxygen Therapy
– Dietary Macros Tracking
– Glucose Metabolism
– CBD Oil
0:00:00 – Introduction and welcome to Dom D'Agostino
0:01:06 – Discussion on ketosis and wine's impact
0:02:53 – Peer-reviewed research on metabolic therapy efficacy
0:03:45 – Ketogenic diet silencing motor impairments in disease
0:06:22 – Ketogenic diet suppresses insulin and mimics fasting
0:07:11 – Brain's metabolic flexibility using ketone bodies
0:08:11 – Keto pet sanctuary treating dogs with cancer
0:10:07 – Whole food nutrition recommendations for dogs
0:13:53 – CNS oxygen toxicity limits underwater time
0:15:31 – Ketones enhance brain energy and resilience
0:17:37 – Dom's personal ketogenic diet experimentation
0:20:41 – Ketogenic diet history and alternatives for epilepsy
0:23:15 – Clinical ketogenic diet ratios explained
0:26:46 – Challenges of social eating on ketogenic diet
0:32:30 – Dom's weight loss and intermittent fasting experience
0:36:40 – Ketogenic diet benefits for elite athletes
0:42:03 – Animal studies on ketogenic diet and survival
0:44:22 – Glut1 deficiency and ketogenic diet therapy
0:47:03 – Book on Alzheimer's and ketogenic interventions
0:50:16 – Daily use of ketone supplements discussion
0:53:24 – Sardines and fatty fish as ideal ketogenic foods
0:56:21 – Environmental toxins in food and impact
0:59:51 – B12 depletion concerns on ketogenic diet
1:02:29 – Magnesium supplementation and epsom salt baths
1:04:09 – Mouse model of ALS and ketogenic diet effects
1:09:02 – Ketones lower blood glucose without clear mechanism
1:16:02 – Ketogenic diet reduces insulin use in diabetes
1:21:45 – Appetite suppression mechanisms in ketogenic diet
1:25:01 – Keto-friendly snacks and product recommendations
1:28:19 – Breath measurement of ketones explained
1:31:14 – Optimizing diet and supplements for ketosis
1:37:21 – Keto ice cream and dessert options
1:42:38 – Gluten sensitivity and diet tolerance discussion
1:46:30 – Ketones as anti-inflammatory signaling molecules
1:53:29 – Interest from NIH and cancer research on ketogenic diet
2:04:12 – Ketone supplements enhance wound healing in rats
2:12:49 – Dom's fasting experience and mental clarity
2:19:01 – Long-term fasting case study and outcomes
2:34:26 – Ketogenic diet studies on strength and performance

Transcript Excerpt

Starting point is 00:00:00 Boom and we're live. How are you Dom? Welcome to the show. I'm doing great Joe. Pull this sucker right up close. There you go. Starting point is 00:00:30 Maybe the dry farm wines guys think that... Starting point is 00:01:06 you can completely stay in ketosis. Interesting. Most glasses, most wine will kick you out of Starting point is 00:01:35 And even beer does. Even though it's supposed Starting point is 00:02:05 mean, this is important for, you know, people that are doing it to manage their health long term. Starting point is 00:02:53 where there's good peer reviewed research to support the efficacy as a metabolic based therapy Starting point is 00:03:45 you can largely silence the pathology and the motor function impairments associated with this disease. And that's amazing to me that you have a disease that is persistently there due to a genetic Starting point is 00:04:27 Okay. Starting point is 00:04:49 14 hours, you know, that's clinical. Starting point is 00:05:41 on eating fat and with a minimal amount of protein, Starting point is 00:06:22 it's suppressing the hormone insulin and kind of mimicking the fuel, the substrate utilization that you would be using in a state of being fasted, Starting point is 00:07:11 The brain has the metabolic flexibility to adapt from using glucose to using primarily ketone bodies. Starting point is 00:08:11 source uh the keto pet sanctuary actually treats dogs uh that have cancer and they implement a Starting point is 00:08:40 Yeah. It's really interesting. I was talking with Ron Penna yesterday from Quest Nutrition, the CEO of Quest Nutrition, and he brought to my attention that if you look on a package of dog food, you won't see carbohydrates listed, even though it's the primary because there was some laws or policy put into action to prevent carbohydrates from even being listed on kibble, on dog food. Starting point is 00:09:41 in fat, relatively speaking. Yeah, but dogs, you know, really should no...

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Frequently asked about this episode

Who was the guest on Joe Rogan Experience #994?

Dom D'Agostino was the guest on JRE #994. This page includes the episode overview, topics discussed, and related resources.

What topics were discussed on JRE #994?

On Joe Rogan Experience #994 with Dom D'Agostino, topics include Ketogenic Diet, Metabolic Therapy, Ketone Supplements, and Epilepsy Treatment.

Where can I read the transcript for JRE #994?

The full searchable transcript for Joe Rogan Experience #994 with Dom D'Agostino is available on this page, along with key topics and timestamps.