Paul Saladino

Date: 2020-10-16 | Duration: 3h 6m

Episode Overview

Paul Saladino dives deep into the benefits and controversies surrounding a carnivore diet, emphasizing the evolutionary context of human nutrition. He challenges common perceptions about plant toxins and oxidative stress, explaining how many plant compounds act as molecular hormetics—mild stressors that trigger antioxidant defenses but can also have negative effects like inhibiting iodine absorption. Saladino highlights the unique nutrient density of animal foods, especially organ meats, which provide essential vitamins and compounds such as vitamin K2, choline, and taurine that are difficult to obtain from plants alone. He shares personal anecdotes about hunting and consuming various animal parts, underscoring the cultural and nutritional significance of nose-to-tail eating. The conversation also explores the impact of modern agriculture and processed vegetable oils on metabolic health, with Saladino pointing to linoleic acid in seed oils as a major driver of inflammation and chronic disease. He critiques the lipid hypothesis of heart disease, arguing that LDL cholesterol must be understood in a broader metabolic context rather than as a standalone risk factor. Additionally, Saladino discusses ketosis and intermittent fasting as metabolic tools that align with ancestral human physiology. Throughout, he weaves in stories from his own hunting experiences and reflections on reconnecting with nature, framing diet as both a biological necessity and a meaningful practice.

About Paul Saladino

Dr. Paul Saladino is a physician and board-certified nutrition specialist renowned for his expertise in the carnivore diet, an unconventional dietary regimen emphasizing animal-based foods. With a medical background that includes an M.D. from the University of Arizona and extensive research in nutritional science, Saladino has garnered attention for the significant health transformations he claims to have facilitated in his patients. His engaging discussions and evidence-based approach to nutrition, particularly on platforms like the Joe Rogan Experience, have made him a provocative figure in the health and wellness community. Saladino's insights challenge conventional dietary norms, sparking conversations about the role of meat in human health, making him a compelling voice in modern nutrition discourse.

Key Moments

– Carnivore Diet
– Molecular Hormesis
– Oxidative Stress
– Nutrient Bioavailability
– Organ Meats Nutrition
– Regenerative Agriculture
– Ketosis and Metabolism
– Lipid and Cholesterol Science
– Indigenous Diets
– Fiber and Digestive Health
– Processed Vegetable Oils
– Intermittent Fasting
– Evolutionary Nutrition
– Vitamin C and Scurvy
– Animal vs Plant Nutrients
– Cholesterol and Cardiovascular Disease
– Desiccated Organ Supplements
– Hunting and Ancestral Lifestyle
– Gut Health and Bile Acids
– Food Processing and Satiety
0:00:29 – Discussion on eating only meat and colon health concerns
0:02:31 – Timeline of plant and animal co-evolution over 500 million years
0:05:44 – Introduction to environmental and molecular hormesis concepts
0:08:04 – Oxidative stress activates NRF2 antioxidant pathway
0:10:30 – Role of myrosinase enzyme in plant compounds
0:11:11 – Goitrogens in plants inhibiting iodine absorption
0:15:05 – Questioning essential vitamins obtained from plants
0:16:33 – Vitamin C minimum doses to prevent scurvy discussed
0:20:16 – Vitamin C blood levels and cold outcomes analyzed
0:22:15 – Importance of eating organ meats versus muscle meat
0:29:16 – Grass-fed, regeneratively raised cattle nutrient quality
0:34:22 – Sustainability and scalability of regenerative agriculture questioned
0:37:21 – Soil carbon content and impact of monocropping discussed
0:41:47 – Introduction to Rome Ranch regenerative farming project
0:45:27 – Fat burning systems and metabolic health explained
0:48:28 – Ketosis benefits and mitochondrial function explored
0:53:42 – Effects of exclusive meat diet on the body reviewed
0:57:20 – Carnivore diet impact on eczema and plant reintroduction experiment
1:01:28 – Evidence supporting carnivore diet benefits presented
1:03:28 – Hadza fallback foods and dietary patterns described
1:07:50 – Fructose intake and uric acid relationship examined
1:10:12 – Species-appropriate human diet concept introduced
1:19:36 – Processed vegetable oils and health implications discussed
1:30:01 – Historical review of sugar, fat, and heart disease studies
1:31:18 – Desiccated organ supplements benefits and usage
1:35:25 – Intermittent fasting timing and benefits debated
1:38:29 – Physical training and endurance strategies shared
1:41:14 – Lipid peroxides and oxidative damage explained
1:42:27 – LDL vs HDL cholesterol differences clarified
1:48:29 – Critique of lipid hypothesis in cardiovascular disease
1:51:17 – High LDL in metabolically healthy individuals discussed
1:54:06 – LDL role in atherosclerosis questioned
2:00:31 – Importance of insulin and glucose monitoring emphasized
2:05:16 – Holistic view on lab markers and health metrics urged
2:09:59 – Case study of diet and health improvements with organ supplements
2:12:36 – Bile acids effects on colon and digestion explained
2:15:01 – Fiber elimination and constipation symptom relief studies
2:24:40 – Personal reflections on hunting and wilderness experiences

Transcript Excerpt

Starting point is 00:00:00 The Joe Rogan Experience. Starting point is 00:00:29 that i eat only meat and they're like well you know if you eat too much meat it causes colon Starting point is 00:00:56 So, like, when I tell people I eat mostly meat, Starting point is 00:01:08 Just steal what they're saying. Starting point is 00:01:26 they'll start to appreciate this. Starting point is 00:01:44 Well, how about people who collect mushrooms? Starting point is 00:02:05 But the point is, most of these things you see are not edible. Starting point is 00:02:31 about the timeline of life on Earth, 500 plus million years of plant and animal co-evolution. Starting point is 00:03:09 during our evolution. But there's a real interesting interaction here. This is warfare. Starting point is 00:03:38 They can't run away from us. Starting point is 00:04:11 prove they're good for us? There's a whole different part of the story. What if we think about it from Starting point is 00:04:46 to eat some of them because there's this thing and and i know you've discussed this as well Starting point is 00:05:18 Is that possible with plants? Starting point is 00:05:44 up with these terms, environmental hormesis and molecular hormesis. I'll grab your book. It's right here. Molecular hormesis is broadly termed xenohormesis by some people. Xeno is this Latin Starting point is 00:06:25 or when you exercise, you do generate reactive oxygen species, superoxide radicals, and they Starting point is 00:06:53 with the loss of electrons being oxidation, Starting point is 00:07:14 the protein. And we know these can be damaging for humans. One of the reasons that cigarette Starting point is 00:07:49 we'll be dead. Starting point is 00:08:04 That oxidative stress turns on NRF2. Starting point is 00:08:25 Molecular hormesis is a little different. It's like going to the pharmacy and taking a medicine. Starting point is 00:09:02 glucose tolerance, and they can affect sympathetic Starting point is 00:09:37 It trig...

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Who was the guest on Joe Rogan Experience #1551?

Paul Saladino was the guest on JRE #1551. This page includes the episode overview, topics discussed, and related resources.

What topics were discussed on JRE #1551?

On Joe Rogan Experience #1551 with Paul Saladino, topics include Carnivore Diet, Molecular Hormesis, Oxidative Stress, and Nutrient Bioavailability.

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